• Version:
  • 11.0 [archived version]
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NOP10 NOP10 PUS1 PUS1 TRMT1 TRMT1 DKC1 DKC1 PUS7 PUS7 RPUSD2 RPUSD2 TRUB1 TRUB1 PUS3 PUS3 PUS10 PUS10 FAM206A FAM206A PEX13 PEX13
"PUS10" - Putative tRNA pseudouridine synthase Pus10 in Homo sapiens
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PUS10Putative tRNA pseudouridine synthase Pus10; Pseudouridylate synthases catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. PUS10 catalyzes the formation of the universal psi55 in the GC loop of transfer RNAs (Probable). Modulator of TRAIL-induced cell death via activation of procaspase 8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death (529 aa)    
Predicted Functional Partners:
FAM206A
Protein Simiate; Family with sequence similarity 206 member A (181 aa)
       
      0.873
PUS3
tRNA pseudouridine(38/39) synthase; Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs; Belongs to the tRNA pseudouridine synthase TruA family (481 aa)
     
   
  0.747
RPUSD2
RNA pseudouridylate synthase domain containing 2 (545 aa)
     
   
  0.684
TRMT1
tRNA (guanine(26)-N(2))-dimethyltransferase; Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family (659 aa)
     
   
  0.682
TRUB1
Probable tRNA pseudouridine synthase 1; May be responsible for synthesis of pseudouridine from uracil in transfer RNAs (349 aa)
     
   
  0.682
PUS7
Pseudouridylate synthase 7 (661 aa)
     
   
  0.673
DKC1
H/ACA ribonucleoprotein complex subunit 4; Isoform 1- Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (’psi’) residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the t [...] (514 aa)
     
   
  0.672
PEX13
Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins; Peroxins (403 aa)
     
   
  0.662
PUS1
tRNA pseudouridine synthase A; Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity possibly through pseudouridylation of SRA1 RNA (By similarity); Belongs to the tRNA pseudouridine synthase TruA family (427 aa)
     
   
  0.649
NOP10
H/ACA ribonucleoprotein complex subunit 3; Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse tran [...] (64 aa)
         
  0.643
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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