ANKDD1A protein (human) - STRING database

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ANKDD1A

Ankyrin repeat and death domain containing 1A (522 aa)

Predicted Functional Partners:

SOWAHD

0.756

CCDC135

0.750

SAMD10

0.726

TAGAP

0.704

HMHA1

0.683

FHL3

0.676

CAPN8

0.668

ARHGAP27

0.645

DGKI

0.625

SH3BP4

0.624

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKDD1A	ARHGAP27	ENSP00000325895	ENSP00000403323	Ankyrin repeat and death domain containing 1A	Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity); Pleckstrin homology domain containing	0.645
ANKDD1A	CAPN8	ENSP00000325895	ENSP00000355837	Ankyrin repeat and death domain containing 1A	Calpain-8; Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta- subunit of coatomer complex (By similarity); Belongs to the peptidase C2 family	0.668
ANKDD1A	CCDC135	ENSP00000325895	ENSP00000353942	Ankyrin repeat and death domain containing 1A	Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family	0.750
ANKDD1A	DGKI	ENSP00000325895	ENSP00000288490	Ankyrin repeat and death domain containing 1A	Diacylglycerol kinase iota; Ankyrin repeat domain containing	0.625
ANKDD1A	FHL3	ENSP00000325895	ENSP00000362107	Ankyrin repeat and death domain containing 1A	Four and a half LIM domains 3	0.676
ANKDD1A	HMHA1	ENSP00000325895	ENSP00000439601	Ankyrin repeat and death domain containing 1A	Rho GTPase-activating protein 45; Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity	0.683
ANKDD1A	SAMD10	ENSP00000325895	ENSP00000358902	Ankyrin repeat and death domain containing 1A	Sterile alpha motif domain containing 10	0.726
ANKDD1A	SH3BP4	ENSP00000325895	ENSP00000386862	Ankyrin repeat and death domain containing 1A	SH3 domain-binding protein 4; May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin- mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy	0.624
ANKDD1A	SOWAHD	ENSP00000325895	ENSP00000340975	Ankyrin repeat and death domain containing 1A	Ankyrin repeat domain-containing protein SOWAHD; Sosondowah ankyrin repeat domain family member D; Belongs to the SOWAH family	0.756
ANKDD1A	TAGAP	ENSP00000325895	ENSP00000356033	Ankyrin repeat and death domain containing 1A	T-cell activation Rho GTPase-activating protein; May function as a GTPase-activating protein and may play important roles during T-cell activation	0.704
ARHGAP27	ANKDD1A	ENSP00000403323	ENSP00000325895	Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity); Pleckstrin homology domain containing	Ankyrin repeat and death domain containing 1A	0.645
ARHGAP27	CAPN8	ENSP00000403323	ENSP00000355837	Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity); Pleckstrin homology domain containing	Calpain-8; Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta- subunit of coatomer complex (By similarity); Belongs to the peptidase C2 family	0.473
ARHGAP27	CCDC135	ENSP00000403323	ENSP00000353942	Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity); Pleckstrin homology domain containing	Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the DRC7 family	0.579
ARHGAP27	DGKI	ENSP00000403323	ENSP00000288490	Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity); Pleckstrin homology domain containing	Diacylglycerol kinase iota; Ankyrin repeat domain containing	0.447
ARHGAP27	FHL3	ENSP00000403323	ENSP00000362107	Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity); Pleckstrin homology domain containing	Four and a half LIM domains 3	0.580
ARHGAP27	HMHA1	ENSP00000403323	ENSP00000439601	Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity); Pleckstrin homology domain containing	Rho GTPase-activating protein 45; Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity	0.467
ARHGAP27	SAMD10	ENSP00000403323	ENSP00000358902	Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity); Pleckstrin homology domain containing	Sterile alpha motif domain containing 10	0.575
ARHGAP27	SH3BP4	ENSP00000403323	ENSP00000386862	Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity); Pleckstrin homology domain containing	SH3 domain-binding protein 4; May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin- mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy	0.458
ARHGAP27	SOWAHD	ENSP00000403323	ENSP00000340975	Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity); Pleckstrin homology domain containing	Ankyrin repeat domain-containing protein SOWAHD; Sosondowah ankyrin repeat domain family member D; Belongs to the SOWAH family	0.634
CAPN8	ANKDD1A	ENSP00000355837	ENSP00000325895	Calpain-8; Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta- subunit of coatomer complex (By similarity); Belongs to the peptidase C2 family	Ankyrin repeat and death domain containing 1A	0.668

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