| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C22orf15 | GUCD1 | ENSP00000384965 | ENSP00000479370 | Uncharacterized protein C22orf15; Chromosome 22 open reading frame 15 | Protein GUCD1; Guanylyl cyclase domain containing 1 | 0.670 |
| C22orf15 | LRRC75B | ENSP00000384965 | ENSP00000320520 | Uncharacterized protein C22orf15; Chromosome 22 open reading frame 15 | Leucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B | 0.703 |
| C22orf15 | SPECC1L | ENSP00000384965 | ENSP00000325785 | Uncharacterized protein C22orf15; Chromosome 22 open reading frame 15 | Cytospin-A; Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration; Belongs to the cytospin-A family | 0.530 |
| GCFC2 | SPECC1L | ENSP00000318690 | ENSP00000325785 | GC-rich sequence DNA-binding factor 2; Factor that represses transcription. It binds to the GC- rich sequences (5’-GCGGGGC-3’) present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters. Involved in pre-mRNA splicing through regulating spliceosome C complex formation. May play a role during late-stage splicing events and turnover of excised inrons; Belongs to the GCF family | Cytospin-A; Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration; Belongs to the cytospin-A family | 0.619 |
| GOLGA5 | HOOK3 | ENSP00000163416 | ENSP00000305699 | Golgin subfamily A member 5; Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport | Protein Hook homolog 3; Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor c [...] | 0.492 |
| GOLGA5 | SPECC1L | ENSP00000163416 | ENSP00000325785 | Golgin subfamily A member 5; Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport | Cytospin-A; Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration; Belongs to the cytospin-A family | 0.503 |
| GUCD1 | C22orf15 | ENSP00000479370 | ENSP00000384965 | Protein GUCD1; Guanylyl cyclase domain containing 1 | Uncharacterized protein C22orf15; Chromosome 22 open reading frame 15 | 0.670 |
| GUCD1 | LRRC75B | ENSP00000479370 | ENSP00000320520 | Protein GUCD1; Guanylyl cyclase domain containing 1 | Leucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B | 0.706 |
| GUCD1 | SPECC1L | ENSP00000479370 | ENSP00000325785 | Protein GUCD1; Guanylyl cyclase domain containing 1 | Cytospin-A; Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration; Belongs to the cytospin-A family | 0.535 |
| HOOK3 | GOLGA5 | ENSP00000305699 | ENSP00000163416 | Protein Hook homolog 3; Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor c [...] | Golgin subfamily A member 5; Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport | 0.492 |
| HOOK3 | SPECC1L | ENSP00000305699 | ENSP00000325785 | Protein Hook homolog 3; Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor c [...] | Cytospin-A; Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration; Belongs to the cytospin-A family | 0.488 |
| LRRC75B | C22orf15 | ENSP00000320520 | ENSP00000384965 | Leucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B | Uncharacterized protein C22orf15; Chromosome 22 open reading frame 15 | 0.703 |
| LRRC75B | GUCD1 | ENSP00000320520 | ENSP00000479370 | Leucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B | Protein GUCD1; Guanylyl cyclase domain containing 1 | 0.706 |
| LRRC75B | SPECC1L | ENSP00000320520 | ENSP00000325785 | Leucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B | Cytospin-A; Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration; Belongs to the cytospin-A family | 0.560 |
| MDC1 | SPECC1L | ENSP00000365588 | ENSP00000325785 | Mediator of DNA damage checkpoint protein 1; Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by ’Ser-139’ phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be a [...] | Cytospin-A; Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration; Belongs to the cytospin-A family | 0.699 |
| MYO5C | SPECC1L | ENSP00000261839 | ENSP00000325785 | Unconventional myosin-Vc; May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues; Myosins, class V | Cytospin-A; Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration; Belongs to the cytospin-A family | 0.481 |
| SLC30A6 | SPECC1L | ENSP00000368648 | ENSP00000325785 | Zinc transporter 6; Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment; Solute carriers | Cytospin-A; Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration; Belongs to the cytospin-A family | 0.533 |
| SPECC1L | C22orf15 | ENSP00000325785 | ENSP00000384965 | Cytospin-A; Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration; Belongs to the cytospin-A family | Uncharacterized protein C22orf15; Chromosome 22 open reading frame 15 | 0.530 |
| SPECC1L | GCFC2 | ENSP00000325785 | ENSP00000318690 | Cytospin-A; Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration; Belongs to the cytospin-A family | GC-rich sequence DNA-binding factor 2; Factor that represses transcription. It binds to the GC- rich sequences (5’-GCGGGGC-3’) present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters. Involved in pre-mRNA splicing through regulating spliceosome C complex formation. May play a role during late-stage splicing events and turnover of excised inrons; Belongs to the GCF family | 0.619 |
| SPECC1L | GOLGA5 | ENSP00000325785 | ENSP00000163416 | Cytospin-A; Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration; Belongs to the cytospin-A family | Golgin subfamily A member 5; Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport | 0.503 |
