| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C8orf22 | SPINK6 | ENSP00000304926 | ENSP00000324870 | Pancreatic progenitor cell differentiation and proliferation factor-like protein; Chromosome 8 open reading frame 22 | Serine protease inhibitor Kazal-type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn’t inhibit KLK8; Serine peptidase inhibitors, Kazal type | 0.692 |
| KLK12 | SPINK5 | ENSP00000250351 | ENSP00000352936 | Kallikrein-12; Kallikrein related peptidase 12; Belongs to the peptidase S1 family. Kallikrein subfamily | Serine protease inhibitor Kazal-type 5; Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense- activating and desquamation-involved proteases. Inhibits KLK5, it’s major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin; Serine peptidase inhibitors, Kazal type | 0.558 |
| KLK12 | SPINK6 | ENSP00000250351 | ENSP00000324870 | Kallikrein-12; Kallikrein related peptidase 12; Belongs to the peptidase S1 family. Kallikrein subfamily | Serine protease inhibitor Kazal-type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn’t inhibit KLK8; Serine peptidase inhibitors, Kazal type | 0.948 |
| KLK13 | SPINK5 | ENSP00000470555 | ENSP00000352936 | Kallikrein-13; Kallikrein related peptidase 13; Kallikreins | Serine protease inhibitor Kazal-type 5; Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense- activating and desquamation-involved proteases. Inhibits KLK5, it’s major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin; Serine peptidase inhibitors, Kazal type | 0.571 |
| KLK13 | SPINK6 | ENSP00000470555 | ENSP00000324870 | Kallikrein-13; Kallikrein related peptidase 13; Kallikreins | Serine protease inhibitor Kazal-type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn’t inhibit KLK8; Serine peptidase inhibitors, Kazal type | 0.949 |
| KLK14 | SPINK5 | ENSP00000375678 | ENSP00000352936 | Kallikrein-14; Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression incl [...] | Serine protease inhibitor Kazal-type 5; Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense- activating and desquamation-involved proteases. Inhibits KLK5, it’s major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin; Serine peptidase inhibitors, Kazal type | 0.836 |
| KLK14 | SPINK6 | ENSP00000375678 | ENSP00000324870 | Kallikrein-14; Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression incl [...] | Serine protease inhibitor Kazal-type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn’t inhibit KLK8; Serine peptidase inhibitors, Kazal type | 0.968 |
| KLK5 | SPINK5 | ENSP00000337733 | ENSP00000352936 | Kallikrein-5; May be involved in desquamation; Belongs to the peptidase S1 family. Kallikrein subfamily | Serine protease inhibitor Kazal-type 5; Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense- activating and desquamation-involved proteases. Inhibits KLK5, it’s major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin; Serine peptidase inhibitors, Kazal type | 0.972 |
| KLK5 | SPINK6 | ENSP00000337733 | ENSP00000324870 | Kallikrein-5; May be involved in desquamation; Belongs to the peptidase S1 family. Kallikrein subfamily | Serine protease inhibitor Kazal-type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn’t inhibit KLK8; Serine peptidase inhibitors, Kazal type | 0.949 |
| SPINK1 | SPINK2 | ENSP00000296695 | ENSP00000425961 | Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similarity); Serine peptidase inhibitors, Kazal type | Serine peptidase inhibitor, Kazal type 2 | 0.901 |
| SPINK1 | SPINK4 | ENSP00000296695 | ENSP00000369045 | Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similarity); Serine peptidase inhibitors, Kazal type | Serine peptidase inhibitor, Kazal type 4 | 0.743 |
| SPINK1 | SPINK5 | ENSP00000296695 | ENSP00000352936 | Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similarity); Serine peptidase inhibitors, Kazal type | Serine protease inhibitor Kazal-type 5; Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense- activating and desquamation-involved proteases. Inhibits KLK5, it’s major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin; Serine peptidase inhibitors, Kazal type | 0.481 |
| SPINK1 | SPINK6 | ENSP00000296695 | ENSP00000324870 | Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similarity); Serine peptidase inhibitors, Kazal type | Serine protease inhibitor Kazal-type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn’t inhibit KLK8; Serine peptidase inhibitors, Kazal type | 0.584 |
| SPINK2 | SPINK1 | ENSP00000425961 | ENSP00000296695 | Serine peptidase inhibitor, Kazal type 2 | Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similarity); Serine peptidase inhibitors, Kazal type | 0.901 |
| SPINK2 | SPINK4 | ENSP00000425961 | ENSP00000369045 | Serine peptidase inhibitor, Kazal type 2 | Serine peptidase inhibitor, Kazal type 4 | 0.624 |
| SPINK2 | SPINK5 | ENSP00000425961 | ENSP00000352936 | Serine peptidase inhibitor, Kazal type 2 | Serine protease inhibitor Kazal-type 5; Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense- activating and desquamation-involved proteases. Inhibits KLK5, it’s major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin; Serine peptidase inhibitors, Kazal type | 0.706 |
| SPINK2 | SPINK6 | ENSP00000425961 | ENSP00000324870 | Serine peptidase inhibitor, Kazal type 2 | Serine protease inhibitor Kazal-type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn’t inhibit KLK8; Serine peptidase inhibitors, Kazal type | 0.731 |
| SPINK2 | SPINK7 | ENSP00000425961 | ENSP00000274565 | Serine peptidase inhibitor, Kazal type 2 | Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor; Serine peptidase inhibitors, Kazal type | 0.653 |
| SPINK4 | SPINK1 | ENSP00000369045 | ENSP00000296695 | Serine peptidase inhibitor, Kazal type 4 | Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similarity); Serine peptidase inhibitors, Kazal type | 0.743 |
| SPINK4 | SPINK2 | ENSP00000369045 | ENSP00000425961 | Serine peptidase inhibitor, Kazal type 4 | Serine peptidase inhibitor, Kazal type 2 | 0.624 |
