• Version:
  • 11.0 [archived version]
STRINGSTRING
PGLYRP2 PGLYRP2 ENSG00000273155 ENSG00000273155 EVI5L EVI5L ASMT ASMT MITD1 MITD1 POGK POGK AKAP17A AKAP17A ZRANB2 ZRANB2 CAAP1 CAAP1 UNC50 UNC50 NOS1AP NOS1AP
"AKAP17A" - A-kinase anchor protein 17A in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
AKAP17AA-kinase anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre- mRNA splicing in a PKA-dependent manner; A-kinase anchoring proteins (695 aa)    
Predicted Functional Partners:
CAAP1
Caspase activity and apoptosis inhibitor 1; Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop (361 aa)
       
      0.825
MITD1
MIT domain-containing protein 1; Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex (249 aa)
     
   
  0.745
ENSG00000273155
annotation not available (131 aa)
           
  0.732
EVI5L
EVI5-like protein; Functions as a GTPase-activating protein (GAP) with a broad specificity (805 aa)
           
  0.721
UNC50
Protein unc-50 homolog; May be involved in cell surface expression of neuronal nicotinic receptors. Binds RNA (By similarity) (259 aa)
           
  0.713
PGLYRP2
N-acetylmuramoyl-L-alanine amidase; May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family (576 aa)
     
   
  0.682
ZRANB2
Zinc finger Ran-binding domain-containing protein 2; Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5’- splice site selection; Zinc fingers RANBP2-type (330 aa)
     
 
  0.682
ASMT
Acetylserotonin O-methyltransferase; Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5- methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity; Pseudoautosomal region 1 (373 aa)
 
       
  0.677
NOS1AP
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity) (506 aa)
       
      0.670
POGK
Pogo transposable element derived with KRAB domain; DNA transposon derived genes (609 aa)
           
  0.663
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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