• Version:
  • 11.0 [archived version]
STRINGSTRING
RNASE7 RNASE7 DEFB103B DEFB103B CAMP CAMP DEFB1 DEFB1 DEFB106A DEFB106A DEFB103A DEFB103A DEFB104B DEFB104B HBD HBD DEFB105B DEFB105B DEFB104A DEFB104A DEFB105A DEFB105A
"DEFB103B" - Beta-defensin 103 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
DEFB103BBeta-defensin 103; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed; Defensins, beta (67 aa)    
Predicted Functional Partners:
DEFB103A
Defensin, beta 103A; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed; Defensins, beta (67 aa)
      
   
0.969
DEFB1
Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family (68 aa)
      
   
  0.952
CAMP
Cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Endogenous ligands (173 aa)
            
  0.839
HBD
Hemoglobin subunit delta; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family (147 aa)
            
  0.808
RNASE7
Ribonuclease 7; Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium; Ribonuclease A family (156 aa)
      
   
  0.798
DEFB105B
Beta-defensin 105; Has antibacterial activity; Defensins, beta (78 aa)
            
  0.773
DEFB105A
Defensin, beta 105A; Has antibacterial activity; Defensins, beta (78 aa)
            
  0.773
DEFB104A
Defensin, beta 104A; Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103; Defensins, beta (72 aa)
            
  0.773
DEFB104B
Beta-defensin 104; Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103; Belongs to the beta-defensin family (72 aa)
            
  0.772
DEFB106A
Beta-defensin 106; Has antibacterial activity. Acts as a ligand for C-C chemokine receptor CCR2; Belongs to the beta-defensin family (65 aa)
            
  0.756
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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