| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C19orf45 | ZNF660 | ENSP00000355241 | ENSP00000324605 | Testis-expressed protein 45; Chromosome 19 open reading frame 45 | Zinc finger protein 660; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.443 |
| CCDC181 | HAPLN3 | ENSP00000356780 | ENSP00000352606 | Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids; Belongs to the CCDC181 family | Hyaluronan and proteoglycan link protein 3; May function in hyaluronic acid binding; V-set domain containing | 0.679 |
| CCDC181 | ZNF660 | ENSP00000356780 | ENSP00000324605 | Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids; Belongs to the CCDC181 family | Zinc finger protein 660; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.559 |
| CREB3L3 | ZNF660 | ENSP00000078445 | ENSP00000324605 | Cyclic AMP-responsive element-binding protein 3-like protein 3; Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression; Basic leucine [...] | Zinc finger protein 660; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.460 |
| HAPLN3 | CCDC181 | ENSP00000352606 | ENSP00000356780 | Hyaluronan and proteoglycan link protein 3; May function in hyaluronic acid binding; V-set domain containing | Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids; Belongs to the CCDC181 family | 0.679 |
| HAPLN3 | ZNF660 | ENSP00000352606 | ENSP00000324605 | Hyaluronan and proteoglycan link protein 3; May function in hyaluronic acid binding; V-set domain containing | Zinc finger protein 660; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.441 |
| HEXIM1 | ZNF660 | ENSP00000328773 | ENSP00000324605 | Protein HEXIM1; Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response a [...] | Zinc finger protein 660; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.444 |
| KIN | ZNF660 | ENSP00000368881 | ENSP00000324605 | DNA/RNA-binding protein KIN17; Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro; Belongs to the KIN17 family | Zinc finger protein 660; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.448 |
| LAGE3 | ZNF660 | ENSP00000349923 | ENSP00000324605 | EKC/KEOPS complex subunit LAGE3; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex (By similarity) | Zinc finger protein 660; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.418 |
| SCUBE3 | ZNF660 | ENSP00000274938 | ENSP00000324605 | Signal peptide, CUB and EGF-like domain-containing protein 3; Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression | Zinc finger protein 660; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.460 |
| TRIM28 | ZNF660 | ENSP00000253024 | ENSP00000324605 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 660; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.903 |
| ZFR | ZNF660 | ENSP00000265069 | ENSP00000324605 | Zinc finger RNA-binding protein; Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity) | Zinc finger protein 660; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.429 |
| ZNF660 | C19orf45 | ENSP00000324605 | ENSP00000355241 | Zinc finger protein 660; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Testis-expressed protein 45; Chromosome 19 open reading frame 45 | 0.443 |
| ZNF660 | CCDC181 | ENSP00000324605 | ENSP00000356780 | Zinc finger protein 660; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids; Belongs to the CCDC181 family | 0.559 |
| ZNF660 | CREB3L3 | ENSP00000324605 | ENSP00000078445 | Zinc finger protein 660; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Cyclic AMP-responsive element-binding protein 3-like protein 3; Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression; Basic leucine [...] | 0.460 |
| ZNF660 | HAPLN3 | ENSP00000324605 | ENSP00000352606 | Zinc finger protein 660; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Hyaluronan and proteoglycan link protein 3; May function in hyaluronic acid binding; V-set domain containing | 0.441 |
| ZNF660 | HEXIM1 | ENSP00000324605 | ENSP00000328773 | Zinc finger protein 660; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Protein HEXIM1; Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response a [...] | 0.444 |
| ZNF660 | KIN | ENSP00000324605 | ENSP00000368881 | Zinc finger protein 660; May be involved in transcriptional regulation; Zinc fingers C2H2-type | DNA/RNA-binding protein KIN17; Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro; Belongs to the KIN17 family | 0.448 |
| ZNF660 | LAGE3 | ENSP00000324605 | ENSP00000349923 | Zinc finger protein 660; May be involved in transcriptional regulation; Zinc fingers C2H2-type | EKC/KEOPS complex subunit LAGE3; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex (By similarity) | 0.418 |
| ZNF660 | SCUBE3 | ENSP00000324605 | ENSP00000274938 | Zinc finger protein 660; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Signal peptide, CUB and EGF-like domain-containing protein 3; Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression | 0.460 |
