node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BPTF | PHF21B | ENSP00000307208 | ENSP00000324403 | Nucleosome-remodeling factor subunit BPTF; Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on ’Lys-4’ (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors; Belongs to the PBTF family | PHD finger protein 21B | 0.565 |
CPNE8 | PHF21B | ENSP00000329748 | ENSP00000324403 | Copine-8; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes; Copines | PHD finger protein 21B | 0.560 |
CPNE8 | POLR3H | ENSP00000329748 | ENSP00000347345 | Copine-8; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes; Copines | DNA-directed RNA polymerase III subunit RPC8; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Ep [...] | 0.503 |
CPNE8 | TBC1D22A | ENSP00000329748 | ENSP00000336724 | Copine-8; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes; Copines | TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s) | 0.546 |
CPNE8 | ZBED4 | ENSP00000329748 | ENSP00000216268 | Copine-8; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes; Copines | Zinc finger BED-type containing 4 | 0.474 |
E2F6 | PHF21B | ENSP00000370936 | ENSP00000324403 | Transcription factor E2F6; Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5’-TTTC[CG]CGC-3’. Has a preference for the 5’-TTTCCCGC-3’ E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexp [...] | PHD finger protein 21B | 0.582 |
HEPACAM | PHF21B | ENSP00000298251 | ENSP00000324403 | Hepatocyte cell adhesion molecule; Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation; Ig-like cell adhesion molecule family | PHD finger protein 21B | 0.594 |
PHF21B | BPTF | ENSP00000324403 | ENSP00000307208 | PHD finger protein 21B | Nucleosome-remodeling factor subunit BPTF; Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on ’Lys-4’ (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors; Belongs to the PBTF family | 0.565 |
PHF21B | CPNE8 | ENSP00000324403 | ENSP00000329748 | PHD finger protein 21B | Copine-8; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes; Copines | 0.560 |
PHF21B | E2F6 | ENSP00000324403 | ENSP00000370936 | PHD finger protein 21B | Transcription factor E2F6; Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5’-TTTC[CG]CGC-3’. Has a preference for the 5’-TTTCCCGC-3’ E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexp [...] | 0.582 |
PHF21B | HEPACAM | ENSP00000324403 | ENSP00000298251 | PHD finger protein 21B | Hepatocyte cell adhesion molecule; Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation; Ig-like cell adhesion molecule family | 0.594 |
PHF21B | POLR3H | ENSP00000324403 | ENSP00000347345 | PHD finger protein 21B | DNA-directed RNA polymerase III subunit RPC8; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Ep [...] | 0.600 |
PHF21B | RCOR2 | ENSP00000324403 | ENSP00000301459 | PHD finger protein 21B | REST corepressor 2; May act as a component of a corepressor complex that represses transcription; Myb/SANT domain containing | 0.573 |
PHF21B | RCOR3 | ENSP00000324403 | ENSP00000413929 | PHD finger protein 21B | REST corepressor 3; May act as a component of a corepressor complex that represses transcription; Belongs to the CoREST family | 0.633 |
PHF21B | RERE | ENSP00000324403 | ENSP00000338629 | PHD finger protein 21B | Arginine-glutamic acid dipeptide repeats protein; Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death; GATA zinc finger domain containing | 0.564 |
PHF21B | TBC1D22A | ENSP00000324403 | ENSP00000336724 | PHD finger protein 21B | TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s) | 0.575 |
PHF21B | ZBED4 | ENSP00000324403 | ENSP00000216268 | PHD finger protein 21B | Zinc finger BED-type containing 4 | 0.582 |
POLR3H | CPNE8 | ENSP00000347345 | ENSP00000329748 | DNA-directed RNA polymerase III subunit RPC8; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Ep [...] | Copine-8; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes; Copines | 0.503 |
POLR3H | PHF21B | ENSP00000347345 | ENSP00000324403 | DNA-directed RNA polymerase III subunit RPC8; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Ep [...] | PHD finger protein 21B | 0.600 |
POLR3H | TBC1D22A | ENSP00000347345 | ENSP00000336724 | DNA-directed RNA polymerase III subunit RPC8; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Ep [...] | TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s) | 0.503 |