• Version:
  • 11.0 [archived version]
STRINGSTRING
HEPACAM HEPACAM RCOR3 RCOR3 E2F6 E2F6 POLR3H POLR3H PHF21B PHF21B TBC1D22A TBC1D22A RERE RERE ZBED4 ZBED4 CPNE8 CPNE8 BPTF BPTF RCOR2 RCOR2
"PHF21B" - PHD finger protein 21B in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
PHF21BPHD finger protein 21B (531 aa)    
Predicted Functional Partners:
RCOR3
REST corepressor 3; May act as a component of a corepressor complex that represses transcription; Belongs to the CoREST family (553 aa)
     
 
  0.633
POLR3H
DNA-directed RNA polymerase III subunit RPC8; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Ep [...] (204 aa)
     
 
  0.600
HEPACAM
Hepatocyte cell adhesion molecule; Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation; Ig-like cell adhesion molecule family (416 aa)
           
  0.594
E2F6
Transcription factor E2F6; Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5’-TTTC[CG]CGC-3’. Has a preference for the 5’-TTTCCCGC-3’ E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexp [...] (281 aa)
     
      0.582
ZBED4
Zinc finger BED-type containing 4 (1171 aa)
     
 
  0.582
TBC1D22A
TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s) (517 aa)
     
   
  0.575
RCOR2
REST corepressor 2; May act as a component of a corepressor complex that represses transcription; Myb/SANT domain containing (523 aa)
     
 
  0.573
BPTF
Nucleosome-remodeling factor subunit BPTF; Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on ’Lys-4’ (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors; Belongs to the PBTF family (2920 aa)
     
 
0.565
RERE
Arginine-glutamic acid dipeptide repeats protein; Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death; GATA zinc finger domain containing (1566 aa)
     
   
  0.564
CPNE8
Copine-8; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes; Copines (564 aa)
           
  0.560
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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