node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC43 | CCDC53 | ENSP00000323782 | ENSP00000240079 | Coiled-coil domain containing 43; Belongs to the CCDC43 family | WASH complex subunit 3; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting; Belongs to the CCDC53 family | 0.761 |
CCDC43 | EFTUD2 | ENSP00000323782 | ENSP00000392094 | Coiled-coil domain containing 43; Belongs to the CCDC43 family | 116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily | 0.680 |
CCDC43 | GOSR2 | ENSP00000323782 | ENSP00000225567 | Coiled-coil domain containing 43; Belongs to the CCDC43 family | Golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network; Belongs to the GOSR2 family | 0.673 |
CCDC43 | GPATCH8 | ENSP00000323782 | ENSP00000467556 | Coiled-coil domain containing 43; Belongs to the CCDC43 family | G-patch domain containing 8 | 0.475 |
CCDC43 | KIAA0196 | ENSP00000323782 | ENSP00000318016 | Coiled-coil domain containing 43; Belongs to the CCDC43 family | WASH complex subunit 5; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting. May be involved in axonal outgrowth. Involved in cellular localization of ADRB2. Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 | 0.709 |
CCDC43 | PNKP | ENSP00000323782 | ENSP00000323511 | Coiled-coil domain containing 43; Belongs to the CCDC43 family | Bifunctional polynucleotide phosphatase/kinase; Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3’-phosphates from, or by phosphorylating 5’-hydroxyl groups on, the ribose sugar of the DNA backbone; HAD Asp-based non-protein phosphatases | 0.516 |
CCDC43 | SCML1 | ENSP00000323782 | ENSP00000369380 | Coiled-coil domain containing 43; Belongs to the CCDC43 family | Sex comb on midleg-like protein 1; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. May be involved in spermatogenesis during sexual maturation (By similarity); Sterile alpha motif domain containing | 0.537 |
CCDC43 | TMEM101 | ENSP00000323782 | ENSP00000468025 | Coiled-coil domain containing 43; Belongs to the CCDC43 family | Transmembrane protein 101; May activate NF-kappa-B signaling pathways | 0.480 |
CCDC43 | ZFP28 | ENSP00000323782 | ENSP00000301318 | Coiled-coil domain containing 43; Belongs to the CCDC43 family | Zinc finger protein 28 homolog; May be involved in transcriptional regulation. May have a role in embryonic development; Zinc fingers C2H2-type | 0.626 |
CCDC43 | ZNF28 | ENSP00000323782 | ENSP00000397693 | Coiled-coil domain containing 43; Belongs to the CCDC43 family | Zinc finger protein 28; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.566 |
CCDC53 | CCDC43 | ENSP00000240079 | ENSP00000323782 | WASH complex subunit 3; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting; Belongs to the CCDC53 family | Coiled-coil domain containing 43; Belongs to the CCDC43 family | 0.761 |
CCDC53 | KIAA0196 | ENSP00000240079 | ENSP00000318016 | WASH complex subunit 3; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting; Belongs to the CCDC53 family | WASH complex subunit 5; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting. May be involved in axonal outgrowth. Involved in cellular localization of ADRB2. Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 | 0.999 |
EFTUD2 | CCDC43 | ENSP00000392094 | ENSP00000323782 | 116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily | Coiled-coil domain containing 43; Belongs to the CCDC43 family | 0.680 |
EFTUD2 | GOSR2 | ENSP00000392094 | ENSP00000225567 | 116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily | Golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network; Belongs to the GOSR2 family | 0.584 |
EFTUD2 | GPATCH8 | ENSP00000392094 | ENSP00000467556 | 116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily | G-patch domain containing 8 | 0.775 |
GOSR2 | CCDC43 | ENSP00000225567 | ENSP00000323782 | Golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network; Belongs to the GOSR2 family | Coiled-coil domain containing 43; Belongs to the CCDC43 family | 0.673 |
GOSR2 | EFTUD2 | ENSP00000225567 | ENSP00000392094 | Golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network; Belongs to the GOSR2 family | 116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily | 0.584 |
GPATCH8 | CCDC43 | ENSP00000467556 | ENSP00000323782 | G-patch domain containing 8 | Coiled-coil domain containing 43; Belongs to the CCDC43 family | 0.475 |
GPATCH8 | EFTUD2 | ENSP00000467556 | ENSP00000392094 | G-patch domain containing 8 | 116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily | 0.775 |
GPATCH8 | TMEM101 | ENSP00000467556 | ENSP00000468025 | G-patch domain containing 8 | Transmembrane protein 101; May activate NF-kappa-B signaling pathways | 0.474 |