CCDC43 protein (human) - STRING database

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CCDC43

Coiled-coil domain containing 43; Belongs to the CCDC43 family (224 aa)

Predicted Functional Partners:

CCDC53

0.761

KIAA0196

0.709

EFTUD2

0.680

GOSR2

0.673

ZFP28

0.626

ZNF28

0.566

SCML1

0.537

PNKP

0.516

TMEM101

0.480

GPATCH8

0.475

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC43	CCDC53	ENSP00000323782	ENSP00000240079	Coiled-coil domain containing 43; Belongs to the CCDC43 family	WASH complex subunit 3; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting; Belongs to the CCDC53 family	0.761
CCDC43	EFTUD2	ENSP00000323782	ENSP00000392094	Coiled-coil domain containing 43; Belongs to the CCDC43 family	116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily	0.680
CCDC43	GOSR2	ENSP00000323782	ENSP00000225567	Coiled-coil domain containing 43; Belongs to the CCDC43 family	Golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network; Belongs to the GOSR2 family	0.673
CCDC43	GPATCH8	ENSP00000323782	ENSP00000467556	Coiled-coil domain containing 43; Belongs to the CCDC43 family	G-patch domain containing 8	0.475
CCDC43	KIAA0196	ENSP00000323782	ENSP00000318016	Coiled-coil domain containing 43; Belongs to the CCDC43 family	WASH complex subunit 5; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting. May be involved in axonal outgrowth. Involved in cellular localization of ADRB2. Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7	0.709
CCDC43	PNKP	ENSP00000323782	ENSP00000323511	Coiled-coil domain containing 43; Belongs to the CCDC43 family	Bifunctional polynucleotide phosphatase/kinase; Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3’-phosphates from, or by phosphorylating 5’-hydroxyl groups on, the ribose sugar of the DNA backbone; HAD Asp-based non-protein phosphatases	0.516
CCDC43	SCML1	ENSP00000323782	ENSP00000369380	Coiled-coil domain containing 43; Belongs to the CCDC43 family	Sex comb on midleg-like protein 1; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. May be involved in spermatogenesis during sexual maturation (By similarity); Sterile alpha motif domain containing	0.537
CCDC43	TMEM101	ENSP00000323782	ENSP00000468025	Coiled-coil domain containing 43; Belongs to the CCDC43 family	Transmembrane protein 101; May activate NF-kappa-B signaling pathways	0.480
CCDC43	ZFP28	ENSP00000323782	ENSP00000301318	Coiled-coil domain containing 43; Belongs to the CCDC43 family	Zinc finger protein 28 homolog; May be involved in transcriptional regulation. May have a role in embryonic development; Zinc fingers C2H2-type	0.626
CCDC43	ZNF28	ENSP00000323782	ENSP00000397693	Coiled-coil domain containing 43; Belongs to the CCDC43 family	Zinc finger protein 28; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.566
CCDC53	CCDC43	ENSP00000240079	ENSP00000323782	WASH complex subunit 3; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting; Belongs to the CCDC53 family	Coiled-coil domain containing 43; Belongs to the CCDC43 family	0.761
CCDC53	KIAA0196	ENSP00000240079	ENSP00000318016	WASH complex subunit 3; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting; Belongs to the CCDC53 family	WASH complex subunit 5; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting. May be involved in axonal outgrowth. Involved in cellular localization of ADRB2. Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7	0.999
EFTUD2	CCDC43	ENSP00000392094	ENSP00000323782	116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily	Coiled-coil domain containing 43; Belongs to the CCDC43 family	0.680
EFTUD2	GOSR2	ENSP00000392094	ENSP00000225567	116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily	Golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network; Belongs to the GOSR2 family	0.584
EFTUD2	GPATCH8	ENSP00000392094	ENSP00000467556	116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily	G-patch domain containing 8	0.775
GOSR2	CCDC43	ENSP00000225567	ENSP00000323782	Golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network; Belongs to the GOSR2 family	Coiled-coil domain containing 43; Belongs to the CCDC43 family	0.673
GOSR2	EFTUD2	ENSP00000225567	ENSP00000392094	Golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network; Belongs to the GOSR2 family	116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily	0.584
GPATCH8	CCDC43	ENSP00000467556	ENSP00000323782	G-patch domain containing 8	Coiled-coil domain containing 43; Belongs to the CCDC43 family	0.475
GPATCH8	EFTUD2	ENSP00000467556	ENSP00000392094	G-patch domain containing 8	116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily	0.775
GPATCH8	TMEM101	ENSP00000467556	ENSP00000468025	G-patch domain containing 8	Transmembrane protein 101; May activate NF-kappa-B signaling pathways	0.474

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