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  • 11.0 [archived version]
STRINGSTRING
ZNF407 ZNF407 SYTL3 SYTL3 SMIM21 SMIM21 ARMC6 ARMC6 ZADH2 ZADH2 TYSND1 TYSND1 CKS2 CKS2 ACAD11 ACAD11 CCNB1 CCNB1 TMEM135 TMEM135 SCARB2 SCARB2
"ZADH2" - Prostaglandin reductase 3 in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ZADH2Prostaglandin reductase 3; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest efficienty towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily (377 aa)    
Predicted Functional Partners:
SMIM21
Small integral membrane protein 21 (101 aa)
            
  0.669
CKS2
Cyclin-dependent kinases regulatory subunit 2; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function (79 aa)
        
      0.667
ZNF407
Zinc finger protein 407; May be involved in transcriptional regulation; Zinc fingers C2H2-type (2248 aa)
      
   
  0.652
ACAD11
Acyl-CoA dehydrogenase family member 11; Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA (780 aa)
   
   
  0.651
TYSND1
Peroxisomal leader peptide-processing protease; Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta- oxidation of fatty acids (566 aa)
      
   
  0.632
CCNB1
G2/mitotic-specific cyclin-B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition; Belongs to the cyclin family. Cyclin AB subfamily (433 aa)
        
      0.618
TMEM135
Transmembrane protein 135; Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L. May be involved in peroxisome organization; Belongs to the TMEM135 family (458 aa)
            
  0.613
ARMC6
Armadillo repeat containing 6 (501 aa)
      
   
  0.597
SYTL3
Synaptotagmin-like protein 3; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity); Synaptotagmin like tandem C2 proteins (610 aa)
            
  0.591
SCARB2
Lysosome membrane protein 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting; Belongs to the CD36 family (478 aa)
      
   
  0.591
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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