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  • 11.0 [archived version]
STRINGSTRING
TTC36 TTC36 TTC4 TTC4 TTC9C TTC9C C18orf21 C18orf21 TTC5 TTC5 TTC39C TTC39C FAM120C FAM120C TMEM19 TMEM19 RIN3 RIN3 CRK CRK BACH2 BACH2
"TTC39C" - Tetratricopeptide repeat domain containing in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TTC39CTetratricopeptide repeat domain containing (583 aa)    
Predicted Functional Partners:
TTC36
Tetratricopeptide repeat domain containing (189 aa)
      
   
  0.634
TTC4
Tetratricopeptide repeat domain containing; Belongs to the TTC4 family (387 aa)
            
  0.626
TTC9C
Tetratricopeptide repeat domain containing; Belongs to the TTC9 family (171 aa)
            
  0.626
TTC5
Tetratricopeptide repeat protein 5; Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2 (By similarity); Tetratricopeptide repeat domain containing (440 aa)
            
  0.626
C18orf21
UPF0711 protein C18orf21; Chromosome 18 open reading frame 21 (220 aa)
            
  0.558
TMEM19
Transmembrane protein 19 (336 aa)
      
   
  0.533
CRK
Adapter molecule crk; Isoform Crk-II- Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling (304 aa)
        
      0.513
RIN3
Ras and Rab interactor 3; Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function; Belongs to the RIN (Ras interaction/interference) family (985 aa)
        
      0.513
BACH2
Transcription regulator protein BACH2; Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1. Positively regulates the nuclear import of actin (By similarity); BTB domain containing (841 aa)
            
  0.493
FAM120C
Constitutive coactivator of PPAR-gamma-like protein 2; Family with sequence similarity 120C; Belongs to the constitutive coactivator of PPAR-gamma family (1096 aa)
            
  0.473
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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