SLC6A18 protein (human) - STRING database

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SLC6A18

Sodium-dependent neutral amino acid transporter B(0)AT3; Functions as a sodium and chloride-dependent neutral amino acid transporter; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A18 subfamily (628 aa)

Predicted Functional Partners:

SLC36A2

0.906

SLC1A7

0.810

CLPTM1L

0.751

SLC5A2

0.722

TMEM27

0.657

CHEK2

0.640

TTC16

0.603

SLC5A1

0.592

OR12D2

0.581

NF1

0.576

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHEK2	NF1	ENSP00000372023	ENSP00000351015	Serine/threonine-protein kinase Chk2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X- R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads [...]	Neurofibromin; Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity; Armadillo-like helical domain containing	0.501
CHEK2	SLC6A18	ENSP00000372023	ENSP00000323549	Serine/threonine-protein kinase Chk2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X- R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads [...]	Sodium-dependent neutral amino acid transporter B(0)AT3; Functions as a sodium and chloride-dependent neutral amino acid transporter; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A18 subfamily	0.640
CLPTM1L	SLC6A18	ENSP00000313854	ENSP00000323549	Cleft lip and palate transmembrane protein 1-like protein; Enhances cisplatin-mediated apoptosis, when overexpressed; Belongs to the CLPTM1 family	Sodium-dependent neutral amino acid transporter B(0)AT3; Functions as a sodium and chloride-dependent neutral amino acid transporter; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A18 subfamily	0.751
NF1	CHEK2	ENSP00000351015	ENSP00000372023	Neurofibromin; Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity; Armadillo-like helical domain containing	Serine/threonine-protein kinase Chk2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X- R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads [...]	0.501
NF1	SLC6A18	ENSP00000351015	ENSP00000323549	Neurofibromin; Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity; Armadillo-like helical domain containing	Sodium-dependent neutral amino acid transporter B(0)AT3; Functions as a sodium and chloride-dependent neutral amino acid transporter; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A18 subfamily	0.576
OR12D2	SLC6A18	ENSP00000373047	ENSP00000323549	Olfactory receptor 12D2; Odorant receptor; Olfactory receptors, family 12	Sodium-dependent neutral amino acid transporter B(0)AT3; Functions as a sodium and chloride-dependent neutral amino acid transporter; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A18 subfamily	0.581
OR12D2	TTC16	ENSP00000373047	ENSP00000362386	Olfactory receptor 12D2; Odorant receptor; Olfactory receptors, family 12	Tetratricopeptide repeat domain containing	0.732
SLC1A7	SLC36A2	ENSP00000478639	ENSP00000334223	Amino acid transporter; Solute carrier family 1 member 7	Proton-coupled amino acid transporter 2; Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids. Transports glycine and proline. Inhibited by sarcosine (By similarity); Belongs to the amino acid/polyamine transporter 2 family	0.829
SLC1A7	SLC5A1	ENSP00000478639	ENSP00000266088	Amino acid transporter; Solute carrier family 1 member 7	Sodium/glucose cotransporter 1; Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2-1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules; Solute carriers	0.529
SLC1A7	SLC6A18	ENSP00000478639	ENSP00000323549	Amino acid transporter; Solute carrier family 1 member 7	Sodium-dependent neutral amino acid transporter B(0)AT3; Functions as a sodium and chloride-dependent neutral amino acid transporter; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A18 subfamily	0.810
SLC1A7	TMEM27	ENSP00000478639	ENSP00000369699	Amino acid transporter; Solute carrier family 1 member 7	Collectrin; Regulator of SNARE complex function. Stimulator of beta cell replication; Belongs to the TMEM27 family	0.568
SLC36A2	SLC1A7	ENSP00000334223	ENSP00000478639	Proton-coupled amino acid transporter 2; Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids. Transports glycine and proline. Inhibited by sarcosine (By similarity); Belongs to the amino acid/polyamine transporter 2 family	Amino acid transporter; Solute carrier family 1 member 7	0.829
SLC36A2	SLC6A18	ENSP00000334223	ENSP00000323549	Proton-coupled amino acid transporter 2; Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids. Transports glycine and proline. Inhibited by sarcosine (By similarity); Belongs to the amino acid/polyamine transporter 2 family	Sodium-dependent neutral amino acid transporter B(0)AT3; Functions as a sodium and chloride-dependent neutral amino acid transporter; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A18 subfamily	0.906
SLC5A1	SLC1A7	ENSP00000266088	ENSP00000478639	Sodium/glucose cotransporter 1; Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2-1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules; Solute carriers	Amino acid transporter; Solute carrier family 1 member 7	0.529
SLC5A1	SLC6A18	ENSP00000266088	ENSP00000323549	Sodium/glucose cotransporter 1; Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2-1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules; Solute carriers	Sodium-dependent neutral amino acid transporter B(0)AT3; Functions as a sodium and chloride-dependent neutral amino acid transporter; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A18 subfamily	0.592
SLC5A2	SLC6A18	ENSP00000327943	ENSP00000323549	Sodium/glucose cotransporter 2; Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1-1; Solute carriers	Sodium-dependent neutral amino acid transporter B(0)AT3; Functions as a sodium and chloride-dependent neutral amino acid transporter; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A18 subfamily	0.722
SLC5A2	TMEM27	ENSP00000327943	ENSP00000369699	Sodium/glucose cotransporter 2; Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1-1; Solute carriers	Collectrin; Regulator of SNARE complex function. Stimulator of beta cell replication; Belongs to the TMEM27 family	0.543
SLC6A18	CHEK2	ENSP00000323549	ENSP00000372023	Sodium-dependent neutral amino acid transporter B(0)AT3; Functions as a sodium and chloride-dependent neutral amino acid transporter; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A18 subfamily	Serine/threonine-protein kinase Chk2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X- R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads [...]	0.640
SLC6A18	CLPTM1L	ENSP00000323549	ENSP00000313854	Sodium-dependent neutral amino acid transporter B(0)AT3; Functions as a sodium and chloride-dependent neutral amino acid transporter; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A18 subfamily	Cleft lip and palate transmembrane protein 1-like protein; Enhances cisplatin-mediated apoptosis, when overexpressed; Belongs to the CLPTM1 family	0.751
SLC6A18	NF1	ENSP00000323549	ENSP00000351015	Sodium-dependent neutral amino acid transporter B(0)AT3; Functions as a sodium and chloride-dependent neutral amino acid transporter; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A18 subfamily	Neurofibromin; Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity; Armadillo-like helical domain containing	0.576

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