node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARMC8 | GID8 | ENSP00000420333 | ENSP00000266069 | Armadillo repeat containing 8 | Glucose-induced degradation protein 8 homolog; GID complex subunit 8 homolog | 0.968 |
ARMC8 | MKLN1 | ENSP00000420333 | ENSP00000323527 | Armadillo repeat containing 8 | Muskelin; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1; CTLH complex | 0.796 |
ARMC8 | RANBP9 | ENSP00000420333 | ENSP00000011619 | Armadillo repeat containing 8 | Ran-binding protein 9; May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity o [...] | 0.895 |
ARMC8 | RMND5A | ENSP00000420333 | ENSP00000283632 | Armadillo repeat containing 8 | Protein RMD5 homolog A; Required for meiotic nuclear division 5 homolog A; CTLH complex | 0.964 |
ARMC8 | WDR26 | ENSP00000420333 | ENSP00000408108 | Armadillo repeat containing 8 | WD repeat-containing protein 26; G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta-gamma- mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation. Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration. [...] | 0.961 |
CCDC11 | MKLN1 | ENSP00000381553 | ENSP00000323527 | Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis | Muskelin; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1; CTLH complex | 0.725 |
GID8 | ARMC8 | ENSP00000266069 | ENSP00000420333 | Glucose-induced degradation protein 8 homolog; GID complex subunit 8 homolog | Armadillo repeat containing 8 | 0.968 |
GID8 | MKLN1 | ENSP00000266069 | ENSP00000323527 | Glucose-induced degradation protein 8 homolog; GID complex subunit 8 homolog | Muskelin; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1; CTLH complex | 0.878 |
GID8 | PAFAH1B1 | ENSP00000266069 | ENSP00000380378 | Glucose-induced degradation protein 8 homolog; GID complex subunit 8 homolog | Platelet-activating factor acetylhydrolase IB subunit alpha; Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet- activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule slid [...] | 0.576 |
GID8 | RANBP9 | ENSP00000266069 | ENSP00000011619 | Glucose-induced degradation protein 8 homolog; GID complex subunit 8 homolog | Ran-binding protein 9; May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity o [...] | 0.882 |
GID8 | RMND5A | ENSP00000266069 | ENSP00000283632 | Glucose-induced degradation protein 8 homolog; GID complex subunit 8 homolog | Protein RMD5 homolog A; Required for meiotic nuclear division 5 homolog A; CTLH complex | 0.988 |
GID8 | WDR26 | ENSP00000266069 | ENSP00000408108 | Glucose-induced degradation protein 8 homolog; GID complex subunit 8 homolog | WD repeat-containing protein 26; G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta-gamma- mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation. Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration. [...] | 0.975 |
KLHDC10 | MKLN1 | ENSP00000334140 | ENSP00000323527 | Kelch domain-containing protein 10; Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5 | Muskelin; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1; CTLH complex | 0.722 |
KLHDC10 | TSGA13 | ENSP00000334140 | ENSP00000406047 | Kelch domain-containing protein 10; Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5 | Testis-specific gene 13 protein; Testis specific 13 | 0.550 |
KLHL2 | MKLN1 | ENSP00000424198 | ENSP00000323527 | Kelch-like protein 2; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors; BTB domain containing | Muskelin; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1; CTLH complex | 0.722 |
KLHL2 | RMND5A | ENSP00000424198 | ENSP00000283632 | Kelch-like protein 2; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors; BTB domain containing | Protein RMD5 homolog A; Required for meiotic nuclear division 5 homolog A; CTLH complex | 0.652 |
MKLN1 | ARMC8 | ENSP00000323527 | ENSP00000420333 | Muskelin; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1; CTLH complex | Armadillo repeat containing 8 | 0.796 |
MKLN1 | CCDC11 | ENSP00000323527 | ENSP00000381553 | Muskelin; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1; CTLH complex | Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis | 0.725 |
MKLN1 | GID8 | ENSP00000323527 | ENSP00000266069 | Muskelin; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1; CTLH complex | Glucose-induced degradation protein 8 homolog; GID complex subunit 8 homolog | 0.878 |
MKLN1 | KLHDC10 | ENSP00000323527 | ENSP00000334140 | Muskelin; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1; CTLH complex | Kelch domain-containing protein 10; Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5 | 0.722 |