node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKAP1 | DPY30 | ENSP00000478212 | ENSP00000345837 | A-kinase anchor protein 1, mitochondrial; Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane; A-kinase anchoring proteins | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at ’Lys-4’, particularly trimethylation. Histone H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 ’Lys-4’ methylation at key developmental loci. May also play an indirect or direct role in endosomal transport; Belongs to the dpy-30 family | 0.442 |
AKAP1 | MYCBP | ENSP00000478212 | ENSP00000380702 | A-kinase anchor protein 1, mitochondrial; Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane; A-kinase anchoring proteins | c-Myc-binding protein; May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC | 0.933 |
AKAP1 | MYCBPAP | ENSP00000478212 | ENSP00000323184 | A-kinase anchor protein 1, mitochondrial; Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane; A-kinase anchoring proteins | MYCBP-associated protein; May play a role in spermatogenesis. May be involved in synaptic processes (By similarity) | 0.758 |
ARL6 | DPY30 | ENSP00000337722 | ENSP00000345837 | ADP-ribosylation factor-like protein 6; Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia (By similarity). Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May regulate cilia assembly and disassembly and subsequent [...] | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at ’Lys-4’, particularly trimethylation. Histone H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 ’Lys-4’ methylation at key developmental loci. May also play an indirect or direct role in endosomal transport; Belongs to the dpy-30 family | 0.496 |
ARL6 | MYCBP | ENSP00000337722 | ENSP00000380702 | ADP-ribosylation factor-like protein 6; Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia (By similarity). Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May regulate cilia assembly and disassembly and subsequent [...] | c-Myc-binding protein; May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC | 0.631 |
ARL6 | MYCBPAP | ENSP00000337722 | ENSP00000323184 | ADP-ribosylation factor-like protein 6; Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia (By similarity). Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May regulate cilia assembly and disassembly and subsequent [...] | MYCBP-associated protein; May play a role in spermatogenesis. May be involved in synaptic processes (By similarity) | 0.771 |
C15orf26 | LYSMD3 | ENSP00000286732 | ENSP00000314518 | Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly | LysM and putative peptidoglycan-binding domain-containing protein 3; LysM domain containing 3 | 0.505 |
C15orf26 | MYCBPAP | ENSP00000286732 | ENSP00000323184 | Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly | MYCBP-associated protein; May play a role in spermatogenesis. May be involved in synaptic processes (By similarity) | 0.530 |
C15orf26 | WSCD1 | ENSP00000286732 | ENSP00000460825 | Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly | WSC domain containing 1 | 0.623 |
DPY30 | AKAP1 | ENSP00000345837 | ENSP00000478212 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at ’Lys-4’, particularly trimethylation. Histone H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 ’Lys-4’ methylation at key developmental loci. May also play an indirect or direct role in endosomal transport; Belongs to the dpy-30 family | A-kinase anchor protein 1, mitochondrial; Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane; A-kinase anchoring proteins | 0.442 |
DPY30 | ARL6 | ENSP00000345837 | ENSP00000337722 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at ’Lys-4’, particularly trimethylation. Histone H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 ’Lys-4’ methylation at key developmental loci. May also play an indirect or direct role in endosomal transport; Belongs to the dpy-30 family | ADP-ribosylation factor-like protein 6; Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia (By similarity). Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May regulate cilia assembly and disassembly and subsequent [...] | 0.496 |
DPY30 | MYCBP | ENSP00000345837 | ENSP00000380702 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at ’Lys-4’, particularly trimethylation. Histone H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 ’Lys-4’ methylation at key developmental loci. May also play an indirect or direct role in endosomal transport; Belongs to the dpy-30 family | c-Myc-binding protein; May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC | 0.442 |
DPY30 | MYCBPAP | ENSP00000345837 | ENSP00000323184 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at ’Lys-4’, particularly trimethylation. Histone H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 ’Lys-4’ methylation at key developmental loci. May also play an indirect or direct role in endosomal transport; Belongs to the dpy-30 family | MYCBP-associated protein; May play a role in spermatogenesis. May be involved in synaptic processes (By similarity) | 0.504 |
LYSMD3 | C15orf26 | ENSP00000314518 | ENSP00000286732 | LysM and putative peptidoglycan-binding domain-containing protein 3; LysM domain containing 3 | Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly | 0.505 |
LYSMD3 | MYCBPAP | ENSP00000314518 | ENSP00000323184 | LysM and putative peptidoglycan-binding domain-containing protein 3; LysM domain containing 3 | MYCBP-associated protein; May play a role in spermatogenesis. May be involved in synaptic processes (By similarity) | 0.539 |
LYSMD3 | WSCD1 | ENSP00000314518 | ENSP00000460825 | LysM and putative peptidoglycan-binding domain-containing protein 3; LysM domain containing 3 | WSC domain containing 1 | 0.581 |
MTHFSD | MYCBPAP | ENSP00000354152 | ENSP00000323184 | Methenyltetrahydrofolate synthase domain-containing protein; Methenyltetrahydrofolate synthetase domain containing; RNA binding motif containing | MYCBP-associated protein; May play a role in spermatogenesis. May be involved in synaptic processes (By similarity) | 0.577 |
MYCBP | AKAP1 | ENSP00000380702 | ENSP00000478212 | c-Myc-binding protein; May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC | A-kinase anchor protein 1, mitochondrial; Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane; A-kinase anchoring proteins | 0.933 |
MYCBP | ARL6 | ENSP00000380702 | ENSP00000337722 | c-Myc-binding protein; May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC | ADP-ribosylation factor-like protein 6; Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia (By similarity). Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May regulate cilia assembly and disassembly and subsequent [...] | 0.631 |
MYCBP | DPY30 | ENSP00000380702 | ENSP00000345837 | c-Myc-binding protein; May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at ’Lys-4’, particularly trimethylation. Histone H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 ’Lys-4’ methylation at key developmental loci. May also play an indirect or direct role in endosomal transport; Belongs to the dpy-30 family | 0.442 |