| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FAM120A | ZKSCAN1 | ENSP00000277165 | ENSP00000323148 | Constitutive coactivator of PPAR-gamma-like protein 1; May participate in mRNA transport in the cytoplasm (By similarity). Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II. May play a pivotal role in the progression of scirrhous- type gastric cancer by supporting cancer cell survival in environments with various oxidative stresses | Zinc finger protein with KRAB and SCAN domains 1; May be involved in transcriptional regulation; SCAN domain containing | 0.589 |
| NOX4 | ZKSCAN1 | ENSP00000263317 | ENSP00000323148 | NADPH oxidase 4; Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and is [...] | Zinc finger protein with KRAB and SCAN domains 1; May be involved in transcriptional regulation; SCAN domain containing | 0.800 |
| PGBD1 | ZKSCAN1 | ENSP00000259883 | ENSP00000323148 | PiggyBac transposable element-derived protein 1; Scavenger receptor cysteine rich domain containing; DNA transposon derived genes | Zinc finger protein with KRAB and SCAN domains 1; May be involved in transcriptional regulation; SCAN domain containing | 0.681 |
| PGBD1 | ZKSCAN4 | ENSP00000259883 | ENSP00000366509 | PiggyBac transposable element-derived protein 1; Scavenger receptor cysteine rich domain containing; DNA transposon derived genes | Zinc finger protein with KRAB and SCAN domains 4; May be involved in the transcriptional activation of MDM2 and EP300 genes; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.862 |
| PGBD1 | ZNF232 | ENSP00000259883 | ENSP00000250076 | PiggyBac transposable element-derived protein 1; Scavenger receptor cysteine rich domain containing; DNA transposon derived genes | Zinc finger protein 232; May be involved in transcriptional regulation; SCAN domain containing | 0.691 |
| PGBD1 | ZNF24 | ENSP00000259883 | ENSP00000261332 | PiggyBac transposable element-derived protein 1; Scavenger receptor cysteine rich domain containing; DNA transposon derived genes | Zinc finger protein 24; Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5’-TCAT-3’ DNA sequence (By similarity). Has transcription repressor activity in vitro; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.828 |
| PGBD1 | ZNF397 | ENSP00000259883 | ENSP00000331577 | PiggyBac transposable element-derived protein 1; Scavenger receptor cysteine rich domain containing; DNA transposon derived genes | Zinc finger protein 397; Isoform 3 acts as a DNA-dependent transcriptional repressor; SCAN domain containing | 0.815 |
| PGBD1 | ZSCAN32 | ENSP00000259883 | ENSP00000380057 | PiggyBac transposable element-derived protein 1; Scavenger receptor cysteine rich domain containing; DNA transposon derived genes | Zinc finger and SCAN domain-containing protein 32; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.828 |
| TRIM28 | ZKSCAN1 | ENSP00000253024 | ENSP00000323148 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein with KRAB and SCAN domains 1; May be involved in transcriptional regulation; SCAN domain containing | 0.903 |
| TRIM28 | ZKSCAN4 | ENSP00000253024 | ENSP00000366509 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein with KRAB and SCAN domains 4; May be involved in the transcriptional activation of MDM2 and EP300 genes; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.906 |
| TRIM28 | ZNF483 | ENSP00000253024 | ENSP00000311679 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 483; May be involved in transcriptional regulation; SCAN domain containing | 0.914 |
| TRIM28 | ZSCAN32 | ENSP00000253024 | ENSP00000380057 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger and SCAN domain-containing protein 32; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.903 |
| ZKSCAN1 | FAM120A | ENSP00000323148 | ENSP00000277165 | Zinc finger protein with KRAB and SCAN domains 1; May be involved in transcriptional regulation; SCAN domain containing | Constitutive coactivator of PPAR-gamma-like protein 1; May participate in mRNA transport in the cytoplasm (By similarity). Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II. May play a pivotal role in the progression of scirrhous- type gastric cancer by supporting cancer cell survival in environments with various oxidative stresses | 0.589 |
| ZKSCAN1 | NOX4 | ENSP00000323148 | ENSP00000263317 | Zinc finger protein with KRAB and SCAN domains 1; May be involved in transcriptional regulation; SCAN domain containing | NADPH oxidase 4; Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and is [...] | 0.800 |
| ZKSCAN1 | PGBD1 | ENSP00000323148 | ENSP00000259883 | Zinc finger protein with KRAB and SCAN domains 1; May be involved in transcriptional regulation; SCAN domain containing | PiggyBac transposable element-derived protein 1; Scavenger receptor cysteine rich domain containing; DNA transposon derived genes | 0.681 |
| ZKSCAN1 | TRIM28 | ENSP00000323148 | ENSP00000253024 | Zinc finger protein with KRAB and SCAN domains 1; May be involved in transcriptional regulation; SCAN domain containing | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.903 |
| ZKSCAN1 | ZKSCAN4 | ENSP00000323148 | ENSP00000366509 | Zinc finger protein with KRAB and SCAN domains 1; May be involved in transcriptional regulation; SCAN domain containing | Zinc finger protein with KRAB and SCAN domains 4; May be involved in the transcriptional activation of MDM2 and EP300 genes; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.672 |
| ZKSCAN1 | ZNF232 | ENSP00000323148 | ENSP00000250076 | Zinc finger protein with KRAB and SCAN domains 1; May be involved in transcriptional regulation; SCAN domain containing | Zinc finger protein 232; May be involved in transcriptional regulation; SCAN domain containing | 0.638 |
| ZKSCAN1 | ZNF24 | ENSP00000323148 | ENSP00000261332 | Zinc finger protein with KRAB and SCAN domains 1; May be involved in transcriptional regulation; SCAN domain containing | Zinc finger protein 24; Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5’-TCAT-3’ DNA sequence (By similarity). Has transcription repressor activity in vitro; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.696 |
| ZKSCAN1 | ZNF397 | ENSP00000323148 | ENSP00000331577 | Zinc finger protein with KRAB and SCAN domains 1; May be involved in transcriptional regulation; SCAN domain containing | Zinc finger protein 397; Isoform 3 acts as a DNA-dependent transcriptional repressor; SCAN domain containing | 0.738 |
