| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GADD45GIP1 | MRPL11 | ENSP00000323065 | ENSP00000308897 | Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis | Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family | 0.997 |
| GADD45GIP1 | MRPL28 | ENSP00000323065 | ENSP00000199706 | Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis | Mitochondrial ribosomal protein L28 | 0.997 |
| GADD45GIP1 | MRPL4 | ENSP00000323065 | ENSP00000253099 | Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis | Mitochondrial ribosomal protein L4; Belongs to the universal ribosomal protein uL4 family | 0.994 |
| GADD45GIP1 | MRPL40 | ENSP00000323065 | ENSP00000333401 | Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis | Mitochondrial ribosomal protein L40; Belongs to the mitochondrion-specific ribosomal protein mL40 family | 0.993 |
| GADD45GIP1 | MRPL41 | ENSP00000323065 | ENSP00000360498 | Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis | 39S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins | 0.996 |
| GADD45GIP1 | MRPL42 | ENSP00000323065 | ENSP00000449884 | Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis | Mitochondrial ribosomal protein L42; Belongs to the mitochondrion-specific ribosomal protein mL42 family | 0.994 |
| GADD45GIP1 | MRPL47 | ENSP00000323065 | ENSP00000417602 | Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis | Mitochondrial ribosomal protein L47 | 0.996 |
| GADD45GIP1 | MRPL50 | ENSP00000323065 | ENSP00000363999 | Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis | Mitochondrial ribosomal protein L50 | 0.996 |
| GADD45GIP1 | MRPS30 | ENSP00000323065 | ENSP00000424328 | Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis | Mitochondrial ribosomal protein S30 | 0.996 |
| GADD45GIP1 | MRPS34 | ENSP00000323065 | ENSP00000177742 | Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis | 28S ribosomal protein S34, mitochondrial; Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation | 0.994 |
| MRPL11 | GADD45GIP1 | ENSP00000308897 | ENSP00000323065 | Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family | Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis | 0.997 |
| MRPL11 | MRPL28 | ENSP00000308897 | ENSP00000199706 | Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family | Mitochondrial ribosomal protein L28 | 0.994 |
| MRPL11 | MRPL4 | ENSP00000308897 | ENSP00000253099 | Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family | Mitochondrial ribosomal protein L4; Belongs to the universal ribosomal protein uL4 family | 0.999 |
| MRPL11 | MRPL40 | ENSP00000308897 | ENSP00000333401 | Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family | Mitochondrial ribosomal protein L40; Belongs to the mitochondrion-specific ribosomal protein mL40 family | 0.998 |
| MRPL11 | MRPL41 | ENSP00000308897 | ENSP00000360498 | Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family | 39S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins | 0.998 |
| MRPL11 | MRPL42 | ENSP00000308897 | ENSP00000449884 | Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family | Mitochondrial ribosomal protein L42; Belongs to the mitochondrion-specific ribosomal protein mL42 family | 0.996 |
| MRPL11 | MRPL47 | ENSP00000308897 | ENSP00000417602 | Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family | Mitochondrial ribosomal protein L47 | 0.996 |
| MRPL11 | MRPL50 | ENSP00000308897 | ENSP00000363999 | Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family | Mitochondrial ribosomal protein L50 | 0.995 |
| MRPL11 | MRPS30 | ENSP00000308897 | ENSP00000424328 | Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family | Mitochondrial ribosomal protein S30 | 0.998 |
| MRPL11 | MRPS34 | ENSP00000308897 | ENSP00000177742 | Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family | 28S ribosomal protein S34, mitochondrial; Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation | 0.991 |
