| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACPT | COPS7A | ENSP00000270593 | ENSP00000438115 | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis | COP9 signalosome complex subunit 7a; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dep [...] | 0.522 |
| ACPT | LANCL1 | ENSP00000270593 | ENSP00000388713 | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis | LanC-like protein 1; May play a role in EPS8 signaling. Binds glutathione | 0.538 |
| ACPT | PRPF31 | ENSP00000270593 | ENSP00000324122 | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis | U4/U6 small nuclear ribonucleoprotein Prp31; Involved in pre-mRNA splicing. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | 0.573 |
| ACPT | ROGDI | ENSP00000270593 | ENSP00000322832 | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis | Protein rogdi homolog; May act as a positive regulator of cell proliferation; Belongs to the rogdi family | 0.725 |
| ACPT | SMYD4 | ENSP00000270593 | ENSP00000304360 | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis | SET and MYND domain containing 4; Belongs to the class V-like SAM-binding methyltransferase superfamily | 0.703 |
| ARID3B | ROGDI | ENSP00000343126 | ENSP00000322832 | AT-rich interactive domain-containing protein 3B; Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A; AT-rich interaction domain containing | Protein rogdi homolog; May act as a positive regulator of cell proliferation; Belongs to the rogdi family | 0.669 |
| ARID3B | ZNF598 | ENSP00000343126 | ENSP00000411409 | AT-rich interactive domain-containing protein 3B; Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A; AT-rich interaction domain containing | E3 ubiquitin-protein ligase ZNF598; E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation. Required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40S ribosomal protein RPS10/eS10, RPS20/uS10 and RPS3/uS3. Stalling precludes synthesis of a long poly-lysine tail and initiates the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide. Also acts as a component of the 4EHP-GYF2 complex, a multipr [...] | 0.525 |
| ARID3B | ZNHIT1 | ENSP00000343126 | ENSP00000304593 | AT-rich interactive domain-containing protein 3B; Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A; AT-rich interaction domain containing | Zinc finger HIT domain-containing protein 1; Seems to play a role in p53-mediated apoptosis induction. Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity; Belongs to the ZNHIT1 family | 0.517 |
| C5orf49 | ROGDI | ENSP00000382708 | ENSP00000322832 | Uncharacterized protein C5orf49; Chromosome 5 open reading frame 49 | Protein rogdi homolog; May act as a positive regulator of cell proliferation; Belongs to the rogdi family | 0.629 |
| COPS7A | ACPT | ENSP00000438115 | ENSP00000270593 | COP9 signalosome complex subunit 7a; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dep [...] | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis | 0.522 |
| COPS7A | LANCL1 | ENSP00000438115 | ENSP00000388713 | COP9 signalosome complex subunit 7a; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dep [...] | LanC-like protein 1; May play a role in EPS8 signaling. Binds glutathione | 0.521 |
| COPS7A | PRPF31 | ENSP00000438115 | ENSP00000324122 | COP9 signalosome complex subunit 7a; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dep [...] | U4/U6 small nuclear ribonucleoprotein Prp31; Involved in pre-mRNA splicing. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | 0.513 |
| COPS7A | ROGDI | ENSP00000438115 | ENSP00000322832 | COP9 signalosome complex subunit 7a; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dep [...] | Protein rogdi homolog; May act as a positive regulator of cell proliferation; Belongs to the rogdi family | 0.609 |
| COPS7A | SMYD4 | ENSP00000438115 | ENSP00000304360 | COP9 signalosome complex subunit 7a; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dep [...] | SET and MYND domain containing 4; Belongs to the class V-like SAM-binding methyltransferase superfamily | 0.533 |
| LANCL1 | ACPT | ENSP00000388713 | ENSP00000270593 | LanC-like protein 1; May play a role in EPS8 signaling. Binds glutathione | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis | 0.538 |
| LANCL1 | COPS7A | ENSP00000388713 | ENSP00000438115 | LanC-like protein 1; May play a role in EPS8 signaling. Binds glutathione | COP9 signalosome complex subunit 7a; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dep [...] | 0.521 |
| LANCL1 | PRPF31 | ENSP00000388713 | ENSP00000324122 | LanC-like protein 1; May play a role in EPS8 signaling. Binds glutathione | U4/U6 small nuclear ribonucleoprotein Prp31; Involved in pre-mRNA splicing. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | 0.583 |
| LANCL1 | ROGDI | ENSP00000388713 | ENSP00000322832 | LanC-like protein 1; May play a role in EPS8 signaling. Binds glutathione | Protein rogdi homolog; May act as a positive regulator of cell proliferation; Belongs to the rogdi family | 0.587 |
| LANCL1 | SMYD4 | ENSP00000388713 | ENSP00000304360 | LanC-like protein 1; May play a role in EPS8 signaling. Binds glutathione | SET and MYND domain containing 4; Belongs to the class V-like SAM-binding methyltransferase superfamily | 0.575 |
| PRPF31 | ACPT | ENSP00000324122 | ENSP00000270593 | U4/U6 small nuclear ribonucleoprotein Prp31; Involved in pre-mRNA splicing. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis | 0.573 |
