| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACAT1 | ACAT2 | ENSP00000265838 | ENSP00000356015 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | 0.947 |
| ACAT1 | CYP51A1 | ENSP00000265838 | ENSP00000003100 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4’-dimethyl cholesta-8,14,24-triene-3-beta-ol; Cytochrome P450 family 51 | 0.609 |
| ACAT1 | FDPS | ENSP00000265838 | ENSP00000349078 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | Farnesyl pyrophosphate synthase; Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate | 0.833 |
| ACAT1 | HMGCR | ENSP00000265838 | ENSP00000287936 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins; Belongs to the HMG-CoA reductase family | 0.857 |
| ACAT1 | HMGCS1 | ENSP00000265838 | ENSP00000322706 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.984 |
| ACAT1 | IDI1 | ENSP00000265838 | ENSP00000370748 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | Isopentenyl-diphosphate Delta-isomerase 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) | 0.812 |
| ACAT1 | MSMO1 | ENSP00000265838 | ENSP00000261507 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | Methylsterol monooxygenase 1; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family | 0.437 |
| ACAT1 | MVD | ENSP00000265838 | ENSP00000301012 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes | 0.871 |
| ACAT1 | SQLE | ENSP00000265838 | ENSP00000265896 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | Squalene monooxygenase; Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway; Belongs to the squalene monooxygenase family | 0.767 |
| ACAT2 | ACAT1 | ENSP00000356015 | ENSP00000265838 | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | 0.947 |
| ACAT2 | CYP51A1 | ENSP00000356015 | ENSP00000003100 | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4’-dimethyl cholesta-8,14,24-triene-3-beta-ol; Cytochrome P450 family 51 | 0.676 |
| ACAT2 | FDPS | ENSP00000356015 | ENSP00000349078 | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | Farnesyl pyrophosphate synthase; Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate | 0.830 |
| ACAT2 | HMGCR | ENSP00000356015 | ENSP00000287936 | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins; Belongs to the HMG-CoA reductase family | 0.825 |
| ACAT2 | HMGCS1 | ENSP00000356015 | ENSP00000322706 | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.989 |
| ACAT2 | IDI1 | ENSP00000356015 | ENSP00000370748 | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | Isopentenyl-diphosphate Delta-isomerase 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) | 0.786 |
| ACAT2 | MSMO1 | ENSP00000356015 | ENSP00000261507 | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | Methylsterol monooxygenase 1; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family | 0.691 |
| ACAT2 | MVD | ENSP00000356015 | ENSP00000301012 | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes | 0.772 |
| ACAT2 | SQLE | ENSP00000356015 | ENSP00000265896 | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | Squalene monooxygenase; Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway; Belongs to the squalene monooxygenase family | 0.832 |
| ACAT2 | SREBF2 | ENSP00000356015 | ENSP00000354476 | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | Sterol regulatory element-binding protein 2; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5’-ATCACCCCAC-3’) found in the flanking region of the LDRL and HMG-CoA synthase genes; Basic helix-loop-helix proteins | 0.444 |
| CYP51A1 | ACAT1 | ENSP00000003100 | ENSP00000265838 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4’-dimethyl cholesta-8,14,24-triene-3-beta-ol; Cytochrome P450 family 51 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | 0.609 |
