ZNF543 protein (human) - STRING database

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ZNF543

Zinc finger protein 543; May be involved in transcriptional regulation; Zinc fingers C2H2-type (600 aa)

Predicted Functional Partners:

TRIM28

0.904

GPATCH2L

0.672

SVOPL

0.558

MYCT1

0.511

OR7G3

0.489

DEFA4

0.446

SGPL1

0.433

PCDHA9

0.430

UHRF1BP1L

0.426

CARD8

0.423

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CARD8	ZNF543	ENSP00000375767	ENSP00000322545	Caspase recruitment domain-containing protein 8; Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases; Caspase recruitment domain containing	Zinc finger protein 543; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.423
DEFA4	ZNF543	ENSP00000297435	ENSP00000322545	Neutrophil defensin 4; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production; Defensins, alpha	Zinc finger protein 543; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.446
GPATCH2L	OR7G3	ENSP00000261530	ENSP00000302867	G patch domain-containing protein 2-like; G-patch domain containing 2 like	Olfactory receptor 7G3; Odorant receptor; Olfactory receptors, family 7	0.487
GPATCH2L	SVOPL	ENSP00000261530	ENSP00000405482	G patch domain-containing protein 2-like; G-patch domain containing 2 like	Putative transporter SVOPL; SVOP like; Belongs to the major facilitator superfamily	0.585
GPATCH2L	UHRF1BP1L	ENSP00000261530	ENSP00000279907	G patch domain-containing protein 2-like; G-patch domain containing 2 like	UHRF1-binding protein 1-like; UHRF1 binding protein 1 like	0.711
GPATCH2L	ZNF543	ENSP00000261530	ENSP00000322545	G patch domain-containing protein 2-like; G-patch domain containing 2 like	Zinc finger protein 543; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.672
MYCT1	ZNF543	ENSP00000356214	ENSP00000322545	Myc target protein 1; May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation (By similarity)	Zinc finger protein 543; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.511
OR7G3	GPATCH2L	ENSP00000302867	ENSP00000261530	Olfactory receptor 7G3; Odorant receptor; Olfactory receptors, family 7	G patch domain-containing protein 2-like; G-patch domain containing 2 like	0.487
OR7G3	UHRF1BP1L	ENSP00000302867	ENSP00000279907	Olfactory receptor 7G3; Odorant receptor; Olfactory receptors, family 7	UHRF1-binding protein 1-like; UHRF1 binding protein 1 like	0.477
OR7G3	ZNF543	ENSP00000302867	ENSP00000322545	Olfactory receptor 7G3; Odorant receptor; Olfactory receptors, family 7	Zinc finger protein 543; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.489
PCDHA9	ZNF543	ENSP00000436042	ENSP00000322545	Protocadherin alpha-9; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins	Zinc finger protein 543; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.430
SGPL1	ZNF543	ENSP00000362298	ENSP00000322545	Sphingosine-1-phosphate lyase 1; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis; Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily	Zinc finger protein 543; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.433
SVOPL	GPATCH2L	ENSP00000405482	ENSP00000261530	Putative transporter SVOPL; SVOP like; Belongs to the major facilitator superfamily	G patch domain-containing protein 2-like; G-patch domain containing 2 like	0.585
SVOPL	ZNF543	ENSP00000405482	ENSP00000322545	Putative transporter SVOPL; SVOP like; Belongs to the major facilitator superfamily	Zinc finger protein 543; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.558
TRIM28	ZNF543	ENSP00000253024	ENSP00000322545	Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...]	Zinc finger protein 543; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.904
UHRF1BP1L	GPATCH2L	ENSP00000279907	ENSP00000261530	UHRF1-binding protein 1-like; UHRF1 binding protein 1 like	G patch domain-containing protein 2-like; G-patch domain containing 2 like	0.711
UHRF1BP1L	OR7G3	ENSP00000279907	ENSP00000302867	UHRF1-binding protein 1-like; UHRF1 binding protein 1 like	Olfactory receptor 7G3; Odorant receptor; Olfactory receptors, family 7	0.477
UHRF1BP1L	ZNF543	ENSP00000279907	ENSP00000322545	UHRF1-binding protein 1-like; UHRF1 binding protein 1 like	Zinc finger protein 543; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.426
ZNF543	CARD8	ENSP00000322545	ENSP00000375767	Zinc finger protein 543; May be involved in transcriptional regulation; Zinc fingers C2H2-type	Caspase recruitment domain-containing protein 8; Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases; Caspase recruitment domain containing	0.423
ZNF543	DEFA4	ENSP00000322545	ENSP00000297435	Zinc finger protein 543; May be involved in transcriptional regulation; Zinc fingers C2H2-type	Neutrophil defensin 4; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production; Defensins, alpha	0.446

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