| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C14orf39 | C3orf38 | ENSP00000324920 | ENSP00000322469 | Protein SIX6OS1; Meiotic protein that localizes to the central element of the synaptonemal complex and is required for chromosome synapsis during meiotic recombination. Required for the appropriate processing of intermediate recombination nodules before crossover formation | Uncharacterized protein C3orf38; May be involved in apoptosis regulation | 0.588 |
| C3orf38 | C14orf39 | ENSP00000322469 | ENSP00000324920 | Uncharacterized protein C3orf38; May be involved in apoptosis regulation | Protein SIX6OS1; Meiotic protein that localizes to the central element of the synaptonemal complex and is required for chromosome synapsis during meiotic recombination. Required for the appropriate processing of intermediate recombination nodules before crossover formation | 0.588 |
| C3orf38 | CGGBP1 | ENSP00000322469 | ENSP00000381429 | Uncharacterized protein C3orf38; May be involved in apoptosis regulation | CGG triplet repeat-binding protein 1; Binds to nonmethylated 5’-d(CGG)(n)-3’ trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter | 0.644 |
| C3orf38 | DNAJB4 | ENSP00000322469 | ENSP00000359799 | Uncharacterized protein C3orf38; May be involved in apoptosis regulation | DnaJ homolog subfamily B member 4; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro); DNAJ heat shock proteins | 0.527 |
| C3orf38 | HTR1A | ENSP00000322469 | ENSP00000316244 | Uncharacterized protein C3orf38; May be involved in apoptosis regulation | 5-hydroxytryptamine receptor 1A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second [...] | 0.626 |
| C3orf38 | NPM3 | ENSP00000322469 | ENSP00000359128 | Uncharacterized protein C3orf38; May be involved in apoptosis regulation | Nucleoplasmin-3; May act as a chaperone | 0.565 |
| C3orf38 | NUBP2 | ENSP00000322469 | ENSP00000262302 | Uncharacterized protein C3orf38; May be involved in apoptosis regulation | Cytosolic Fe-S cluster assembly factor NUBP2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure | 0.664 |
| C3orf38 | POLK | ENSP00000322469 | ENSP00000241436 | Uncharacterized protein C3orf38; May be involved in apoptosis regulation | DNA polymerase kappa; DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3’-5’ proofreading exonuclease activity. Forms a Schiff base with 5’-deoxyribose phosphate at abasic sites, but does not have lyase activity | 0.522 |
| C3orf38 | THOC3 | ENSP00000322469 | ENSP00000265097 | Uncharacterized protein C3orf38; May be involved in apoptosis regulation | THO complex subunit 3; Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5’ end of the mRNA where it functions in mRNA export to the cyt [...] | 0.532 |
| C3orf38 | USPL1 | ENSP00000322469 | ENSP00000255304 | Uncharacterized protein C3orf38; May be involved in apoptosis regulation | SUMO-specific isopeptidase USPL1; SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms. Plays a key role in RNA polymerase-II- mediated snRNA transcription in the Cajal bodies. Is a component of complexes that can bind to U snRNA genes | 0.521 |
| C3orf38 | ZNF654 | ENSP00000322469 | ENSP00000312141 | Uncharacterized protein C3orf38; May be involved in apoptosis regulation | Zinc finger protein 654; May be involved in transcriptional regulation | 0.942 |
| CGGBP1 | C3orf38 | ENSP00000381429 | ENSP00000322469 | CGG triplet repeat-binding protein 1; Binds to nonmethylated 5’-d(CGG)(n)-3’ trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter | Uncharacterized protein C3orf38; May be involved in apoptosis regulation | 0.644 |
| CGGBP1 | ZNF654 | ENSP00000381429 | ENSP00000312141 | CGG triplet repeat-binding protein 1; Binds to nonmethylated 5’-d(CGG)(n)-3’ trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter | Zinc finger protein 654; May be involved in transcriptional regulation | 0.654 |
| DNAJB4 | C3orf38 | ENSP00000359799 | ENSP00000322469 | DnaJ homolog subfamily B member 4; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro); DNAJ heat shock proteins | Uncharacterized protein C3orf38; May be involved in apoptosis regulation | 0.527 |
| DNAJB4 | NPM3 | ENSP00000359799 | ENSP00000359128 | DnaJ homolog subfamily B member 4; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro); DNAJ heat shock proteins | Nucleoplasmin-3; May act as a chaperone | 0.462 |
| HTR1A | C3orf38 | ENSP00000316244 | ENSP00000322469 | 5-hydroxytryptamine receptor 1A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second [...] | Uncharacterized protein C3orf38; May be involved in apoptosis regulation | 0.626 |
| NPM3 | C3orf38 | ENSP00000359128 | ENSP00000322469 | Nucleoplasmin-3; May act as a chaperone | Uncharacterized protein C3orf38; May be involved in apoptosis regulation | 0.565 |
| NPM3 | DNAJB4 | ENSP00000359128 | ENSP00000359799 | Nucleoplasmin-3; May act as a chaperone | DnaJ homolog subfamily B member 4; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro); DNAJ heat shock proteins | 0.462 |
| NPM3 | NUBP2 | ENSP00000359128 | ENSP00000262302 | Nucleoplasmin-3; May act as a chaperone | Cytosolic Fe-S cluster assembly factor NUBP2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure | 0.573 |
| NUBP2 | C3orf38 | ENSP00000262302 | ENSP00000322469 | Cytosolic Fe-S cluster assembly factor NUBP2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure | Uncharacterized protein C3orf38; May be involved in apoptosis regulation | 0.664 |
