VNN2 protein (human) - STRING database

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VNN2

Vascular non-inflammatory molecule 2; Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil; Vanins (520 aa)

Predicted Functional Partners:

FCGR3B

0.943

TEX101

0.936

CD52

0.925

SPACA4

0.918

CEACAM7

0.916

VNN1

0.915

VNN3

0.914

FOLR2

0.910

THY1

0.909

BST1

0.908

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BST1	CD52	ENSP00000265016	ENSP00000363330	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth; Belongs to the ADP-ribosyl cyclase family	CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role; CD molecules	0.920
BST1	CEACAM7	ENSP00000265016	ENSP00000006724	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth; Belongs to the ADP-ribosyl cyclase family	Carcinoembryonic antigen related cell adhesion molecule family; Belongs to the immunoglobulin superfamily. CEA family	0.900
BST1	FCGR3B	ENSP00000265016	ENSP00000433642	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth; Belongs to the ADP-ribosyl cyclase family	Low affinity immunoglobulin gamma Fc region receptor III-B; Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils; CD molecules	0.904
BST1	FOLR2	ENSP00000265016	ENSP00000298223	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth; Belongs to the ADP-ribosyl cyclase family	Folate receptor beta; Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release	0.900
BST1	SPACA4	ENSP00000265016	ENSP00000312774	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth; Belongs to the ADP-ribosyl cyclase family	Sperm acrosome membrane-associated protein 4; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization; LY6/PLAUR domain containing	0.900
BST1	TEX101	ENSP00000265016	ENSP00000472308	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth; Belongs to the ADP-ribosyl cyclase family	Testis-expressed protein 101; Plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct (By similarity). May play a role in signal transduction and promote protein tyrosine phosphorylation (By similarity); LY6/PLAUR domain containing	0.902
BST1	THY1	ENSP00000265016	ENSP00000284240	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth; Belongs to the ADP-ribosyl cyclase family	Thy-1 membrane glycoprotein; May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain; CD molecules	0.911
BST1	VNN1	ENSP00000265016	ENSP00000356905	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth; Belongs to the ADP-ribosyl cyclase family	Pantetheinase; Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine; Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family	0.905
BST1	VNN2	ENSP00000265016	ENSP00000322276	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth; Belongs to the ADP-ribosyl cyclase family	Vascular non-inflammatory molecule 2; Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil; Vanins	0.908
BST1	VNN3	ENSP00000265016	ENSP00000440594	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth; Belongs to the ADP-ribosyl cyclase family	Vascular non-inflammatory molecule 3; Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine; Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family	0.904
CD52	BST1	ENSP00000363330	ENSP00000265016	CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role; CD molecules	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth; Belongs to the ADP-ribosyl cyclase family	0.920
CD52	CEACAM7	ENSP00000363330	ENSP00000006724	CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role; CD molecules	Carcinoembryonic antigen related cell adhesion molecule family; Belongs to the immunoglobulin superfamily. CEA family	0.900
CD52	FCGR3B	ENSP00000363330	ENSP00000433642	CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role; CD molecules	Low affinity immunoglobulin gamma Fc region receptor III-B; Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils; CD molecules	0.935
CD52	FOLR2	ENSP00000363330	ENSP00000298223	CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role; CD molecules	Folate receptor beta; Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release	0.912
CD52	SPACA4	ENSP00000363330	ENSP00000312774	CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role; CD molecules	Sperm acrosome membrane-associated protein 4; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization; LY6/PLAUR domain containing	0.900
CD52	TEX101	ENSP00000363330	ENSP00000472308	CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role; CD molecules	Testis-expressed protein 101; Plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct (By similarity). May play a role in signal transduction and promote protein tyrosine phosphorylation (By similarity); LY6/PLAUR domain containing	0.900
CD52	THY1	ENSP00000363330	ENSP00000284240	CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role; CD molecules	Thy-1 membrane glycoprotein; May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain; CD molecules	0.906
CD52	VNN1	ENSP00000363330	ENSP00000356905	CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role; CD molecules	Pantetheinase; Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine; Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family	0.904
CD52	VNN2	ENSP00000363330	ENSP00000322276	CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role; CD molecules	Vascular non-inflammatory molecule 2; Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil; Vanins	0.925
CD52	VNN3	ENSP00000363330	ENSP00000440594	CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role; CD molecules	Vascular non-inflammatory molecule 3; Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine; Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family	0.900

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