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STRINGSTRING
BTBD9 BTBD9 NOC3L NOC3L AGAP6 AGAP6 GRAMD1A GRAMD1A AGAP4 AGAP4 GPATCH2 GPATCH2 ANKRD31 ANKRD31 ZNF620 ZNF620 MGRN1 MGRN1 TRIM28 TRIM28 USP43 USP43
"ZNF620" - Zinc finger protein 620 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurence
Coexpression
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[Homology]
Score
ZNF620Zinc finger protein 620; May be involved in transcriptional regulation; Zinc fingers C2H2-type (422 aa)    
Predicted Functional Partners:
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
      
  0.917
AGAP6
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6; Putative GTPase-activating protein; Ankyrin repeat domain containing (686 aa)
        
 
  0.648
ANKRD31
Putative ankyrin repeat domain-containing protein 31; Ankyrin repeat domain containing (1873 aa)
            
  0.575
GRAMD1A
GRAM domain-containing protein 1A; May play a role in tumor progression; GRAM domain containing (724 aa)
      
   
  0.565
AGAP4
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4; Putative GTPase-activating protein; Ankyrin repeat domain containing (663 aa)
        
 
  0.514
NOC3L
Nucleolar complex protein 3 homolog; May be required for adipogenesis; Armadillo-like helical domain containing (800 aa)
        
 
  0.467
USP43
Ubiquitin carboxyl-terminal hydrolase 43; May recognize and hydrolyze the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly- ubiquitin precursors as well as that of ubiquitinated proteins (By similarity); Belongs to the peptidase C19 family (1123 aa)
      
 
  0.456
GPATCH2
G patch domain-containing protein 2; Enhances the ATPase activity of DHX15 in vitro; G-patch domain containing (528 aa)
      
   
  0.426
MGRN1
E3 ubiquitin-protein ligase MGRN1; E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to- lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination; Ring finger proteins (576 aa)
      
   
  0.411
BTBD9
BTB/POZ domain-containing protein 9; BTB domain containing 9 (612 aa)
            
  0.406
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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