PGA3 protein (human) - STRING database

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

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experimentally determined

Predicted Interactions

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Score

PGA3

Pepsin A-3; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (388 aa)

Predicted Functional Partners:

PGA4

0.960

SFTPB

0.904

SFTPC

0.900

PGA5

0.808

CTRB2

0.708

CTRB1

0.670

PRSS3P2

0.660

PRSS1

0.592

PRSS3

0.589

ERICH4

0.475

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTRB1	CTRB2	ENSP00000354294	ENSP00000303963	Chymotrypsinogen B1; Belongs to the peptidase S1 family	Chymotrypsinogen B2; Belongs to the peptidase S1 family	0.848
CTRB1	PGA3	ENSP00000354294	ENSP00000322192	Chymotrypsinogen B1; Belongs to the peptidase S1 family	Pepsin A-3; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent	0.670
CTRB1	PGA4	ENSP00000354294	ENSP00000367391	Chymotrypsinogen B1; Belongs to the peptidase S1 family	Pepsin A-4; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent; Belongs to the peptidase A1 family	0.670
CTRB1	PGA5	ENSP00000354294	ENSP00000309542	Chymotrypsinogen B1; Belongs to the peptidase S1 family	Pepsin A-5; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent	0.573
CTRB1	PRSS1	ENSP00000354294	ENSP00000308720	Chymotrypsinogen B1; Belongs to the peptidase S1 family	Trypsin-1; Has activity against the synthetic substrates Boc-Phe- Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val- Pro-Arg-Mec. The single-chain form is more active than the two- chain form against all of these substrates; Belongs to the peptidase S1 family	0.529
CTRB1	PRSS3	ENSP00000354294	ENSP00000354280	Chymotrypsinogen B1; Belongs to the peptidase S1 family	Trypsin-3; Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5; Belongs to the peptidase S1 family	0.492
CTRB1	PRSS3P2	ENSP00000354294	ENSP00000485444	Chymotrypsinogen B1; Belongs to the peptidase S1 family	Trypsin-2; In the ileum, may be involved in defensin processing, including DEFA5; Belongs to the peptidase S1 family	0.573
CTRB2	CTRB1	ENSP00000303963	ENSP00000354294	Chymotrypsinogen B2; Belongs to the peptidase S1 family	Chymotrypsinogen B1; Belongs to the peptidase S1 family	0.848
CTRB2	PGA3	ENSP00000303963	ENSP00000322192	Chymotrypsinogen B2; Belongs to the peptidase S1 family	Pepsin A-3; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent	0.708
CTRB2	PGA4	ENSP00000303963	ENSP00000367391	Chymotrypsinogen B2; Belongs to the peptidase S1 family	Pepsin A-4; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent; Belongs to the peptidase A1 family	0.710
CTRB2	PGA5	ENSP00000303963	ENSP00000309542	Chymotrypsinogen B2; Belongs to the peptidase S1 family	Pepsin A-5; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent	0.641
CTRB2	PRSS1	ENSP00000303963	ENSP00000308720	Chymotrypsinogen B2; Belongs to the peptidase S1 family	Trypsin-1; Has activity against the synthetic substrates Boc-Phe- Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val- Pro-Arg-Mec. The single-chain form is more active than the two- chain form against all of these substrates; Belongs to the peptidase S1 family	0.519
CTRB2	PRSS3	ENSP00000303963	ENSP00000354280	Chymotrypsinogen B2; Belongs to the peptidase S1 family	Trypsin-3; Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5; Belongs to the peptidase S1 family	0.498
CTRB2	PRSS3P2	ENSP00000303963	ENSP00000485444	Chymotrypsinogen B2; Belongs to the peptidase S1 family	Trypsin-2; In the ileum, may be involved in defensin processing, including DEFA5; Belongs to the peptidase S1 family	0.540
ERICH4	PGA3	ENSP00000367429	ENSP00000322192	Glutamate-rich protein 4; Glutamate rich 4	Pepsin A-3; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent	0.475
PGA3	CTRB1	ENSP00000322192	ENSP00000354294	Pepsin A-3; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent	Chymotrypsinogen B1; Belongs to the peptidase S1 family	0.670
PGA3	CTRB2	ENSP00000322192	ENSP00000303963	Pepsin A-3; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent	Chymotrypsinogen B2; Belongs to the peptidase S1 family	0.708
PGA3	ERICH4	ENSP00000322192	ENSP00000367429	Pepsin A-3; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent	Glutamate-rich protein 4; Glutamate rich 4	0.475
PGA3	PGA4	ENSP00000322192	ENSP00000367391	Pepsin A-3; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent	Pepsin A-4; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent; Belongs to the peptidase A1 family	0.960
PGA3	PGA5	ENSP00000322192	ENSP00000309542	Pepsin A-3; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent	Pepsin A-5; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent	0.808

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