SLC25A22 protein (human) - STRING database

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SLC25A22

Mitochondrial glutamate carrier 1; Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+); Belongs to the mitochondrial carrier (TC 2.A.29) family (323 aa)

Predicted Functional Partners:

GUCA1A

0.906

SLC25A18

0.696

CDKL5

0.681

PNKP

0.666

STXBP1

0.663

PCDH19

0.641

PCDH10

0.641

KCNT1

0.637

ARX

0.626

ARHGEF9

0.621

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF9	ARX	ENSP00000253401	ENSP00000368332	Rho guanine nucleotide exchange factor 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters; Pleckstrin homology domain containing	Homeobox protein ARX; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate; Belongs to the paired homeobox family. Bicoid subfamily	0.645
ARHGEF9	CDKL5	ENSP00000253401	ENSP00000369325	Rho guanine nucleotide exchange factor 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters; Pleckstrin homology domain containing	Cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2; Cilia and flagella associated	0.451
ARHGEF9	KCNT1	ENSP00000253401	ENSP00000360822	Rho guanine nucleotide exchange factor 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters; Pleckstrin homology domain containing	Potassium channel subfamily T member 1; Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity); Belongs to the potassium channel family. Calcium- activated (TC 1.A.1.3) subfamily. KCa4.1/KCNT1 sub-subfamily	0.448
ARHGEF9	PCDH10	ENSP00000253401	ENSP00000264360	Rho guanine nucleotide exchange factor 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters; Pleckstrin homology domain containing	Protocadherin-10; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins	0.567
ARHGEF9	PCDH19	ENSP00000253401	ENSP00000362125	Rho guanine nucleotide exchange factor 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters; Pleckstrin homology domain containing	Protocadherin-19; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins	0.563
ARHGEF9	PNKP	ENSP00000253401	ENSP00000323511	Rho guanine nucleotide exchange factor 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters; Pleckstrin homology domain containing	Bifunctional polynucleotide phosphatase/kinase; Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3’-phosphates from, or by phosphorylating 5’-hydroxyl groups on, the ribose sugar of the DNA backbone; HAD Asp-based non-protein phosphatases	0.539
ARHGEF9	SLC25A22	ENSP00000253401	ENSP00000322020	Rho guanine nucleotide exchange factor 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters; Pleckstrin homology domain containing	Mitochondrial glutamate carrier 1; Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+); Belongs to the mitochondrial carrier (TC 2.A.29) family	0.621
ARHGEF9	STXBP1	ENSP00000253401	ENSP00000362399	Rho guanine nucleotide exchange factor 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters; Pleckstrin homology domain containing	Syntaxin-binding protein 1; May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1-1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions	0.528
ARX	ARHGEF9	ENSP00000368332	ENSP00000253401	Homeobox protein ARX; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate; Belongs to the paired homeobox family. Bicoid subfamily	Rho guanine nucleotide exchange factor 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters; Pleckstrin homology domain containing	0.645
ARX	CDKL5	ENSP00000368332	ENSP00000369325	Homeobox protein ARX; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate; Belongs to the paired homeobox family. Bicoid subfamily	Cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2; Cilia and flagella associated	0.625
ARX	PCDH10	ENSP00000368332	ENSP00000264360	Homeobox protein ARX; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate; Belongs to the paired homeobox family. Bicoid subfamily	Protocadherin-10; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins	0.511
ARX	PCDH19	ENSP00000368332	ENSP00000362125	Homeobox protein ARX; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate; Belongs to the paired homeobox family. Bicoid subfamily	Protocadherin-19; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins	0.729
ARX	PNKP	ENSP00000368332	ENSP00000323511	Homeobox protein ARX; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate; Belongs to the paired homeobox family. Bicoid subfamily	Bifunctional polynucleotide phosphatase/kinase; Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3’-phosphates from, or by phosphorylating 5’-hydroxyl groups on, the ribose sugar of the DNA backbone; HAD Asp-based non-protein phosphatases	0.649
ARX	SLC25A22	ENSP00000368332	ENSP00000322020	Homeobox protein ARX; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate; Belongs to the paired homeobox family. Bicoid subfamily	Mitochondrial glutamate carrier 1; Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+); Belongs to the mitochondrial carrier (TC 2.A.29) family	0.626
ARX	STXBP1	ENSP00000368332	ENSP00000362399	Homeobox protein ARX; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate; Belongs to the paired homeobox family. Bicoid subfamily	Syntaxin-binding protein 1; May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1-1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions	0.655
CDKL5	ARHGEF9	ENSP00000369325	ENSP00000253401	Cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2; Cilia and flagella associated	Rho guanine nucleotide exchange factor 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters; Pleckstrin homology domain containing	0.451
CDKL5	ARX	ENSP00000369325	ENSP00000368332	Cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2; Cilia and flagella associated	Homeobox protein ARX; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate; Belongs to the paired homeobox family. Bicoid subfamily	0.625
CDKL5	KCNT1	ENSP00000369325	ENSP00000360822	Cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2; Cilia and flagella associated	Potassium channel subfamily T member 1; Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity); Belongs to the potassium channel family. Calcium- activated (TC 1.A.1.3) subfamily. KCa4.1/KCNT1 sub-subfamily	0.617
CDKL5	PCDH10	ENSP00000369325	ENSP00000264360	Cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2; Cilia and flagella associated	Protocadherin-10; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins	0.684
CDKL5	PCDH19	ENSP00000369325	ENSP00000362125	Cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2; Cilia and flagella associated	Protocadherin-19; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins	0.746

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