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  • 11.0 [archived version]
STRINGSTRING
KDM1A KDM1A DUX4L7 DUX4L7 DUX4L1 DUX4L1 DUX4L8 DUX4L8 PRAMEF2 PRAMEF2 ZSCAN4 ZSCAN4 DUX4 DUX4 TRIM43 TRIM43 TBX3 TBX3 MBD3L2 MBD3L2 PRAMEF1 PRAMEF1
"ZSCAN4" - Zinc finger and SCAN domain-containing protein 4 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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ZSCAN4Zinc finger and SCAN domain-containing protein 4; Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity); SCAN domain containing (433 aa)    
Predicted Functional Partners:
DUX4
Double homeobox protein 4; Involved in transcriptional regulation. May regulate microRNA (miRNA) expression; Belongs to the paired homeobox family (424 aa)
        
 
  0.797
DUX4L8
Double homeodomain protein DUX4-s; PRD class homeoboxes and pseudogenes (424 aa)
        
 
  0.796
DUX4L7
Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes (424 aa)
        
 
  0.796
DUX4L1
Double homeobox 4 like 1; PRD class homeoboxes and pseudogenes (424 aa)
        
 
  0.788
TRIM43
Tripartite motif containing 43; Ring finger proteins (446 aa)
      
 
  0.687
KDM1A
Lysine-specific histone demethylase 1A; Histone demethylase that demethylates both ’Lys-4’ (H3K4me) and ’Lys-9’ (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethyl [...] (876 aa)
      
 
  0.681
TBX3
T-box transcription factor TBX3; Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence; T-boxes (743 aa)
        
 
  0.678
MBD3L2
methyl-CpG binding domain protein 3 like 2; Belongs to the MBD3L family (208 aa)
      
 
  0.678
PRAMEF2
PRAME family member 2; Belongs to the PRAME family (474 aa)
      
   
  0.653
PRAMEF1
PRAME family member 1; Belongs to the PRAME family (474 aa)
            
  0.651
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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