| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKR1E2 | ZNF776 | ENSP00000298375 | ENSP00000321812 | 1,5-anhydro-D-fructose reductase; Catalyzes the NADPH-dependent reduction of 1,5-anhydro- D-fructose (AF) to 1,5-anhydro-D-glucitol (By similarity). Has low NADPH-dependent reductase activity towards 9,10- phenanthrenequinone (in vitro) | Zinc finger protein 776; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.544 |
| CPNE4 | ZNF776 | ENSP00000478878 | ENSP00000321812 | Copine-4; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes; Belongs to the copine family | Zinc finger protein 776; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.472 |
| DYRK4 | ZNF776 | ENSP00000441755 | ENSP00000321812 | Dual specificity tyrosine-phosphorylation-regulated kinase 4; Possible non-essential role in spermiogenesis; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily | Zinc finger protein 776; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.499 |
| FERD3L | ZNF776 | ENSP00000275461 | ENSP00000321812 | Fer3-like protein; Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins (By similarity); Basic helix-loop-helix proteins | Zinc finger protein 776; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.478 |
| NSUN4 | ZNF776 | ENSP00000419740 | ENSP00000321812 | 5-methylcytosine rRNA methyltransferase NSUN4; Involved in mitochondrial ribosome assembly. 5- methylcytosine rRNA methyltransferase that probably is involved in mitochondrial ribosome small subunit (SSU) maturation by methylation of mitochondrial 12S rRNA; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled. In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4; [...] | Zinc finger protein 776; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.471 |
| SSBP2 | ZNF776 | ENSP00000483921 | ENSP00000321812 | Single stranded DNA binding protein 2 | Zinc finger protein 776; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.404 |
| TMEM219 | ZNF776 | ENSP00000457492 | ENSP00000321812 | Insulin-like growth factor-binding protein 3 receptor; Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding | Zinc finger protein 776; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.516 |
| TRIM28 | ZNF776 | ENSP00000253024 | ENSP00000321812 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 776; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.903 |
| ZNF776 | AKR1E2 | ENSP00000321812 | ENSP00000298375 | Zinc finger protein 776; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 1,5-anhydro-D-fructose reductase; Catalyzes the NADPH-dependent reduction of 1,5-anhydro- D-fructose (AF) to 1,5-anhydro-D-glucitol (By similarity). Has low NADPH-dependent reductase activity towards 9,10- phenanthrenequinone (in vitro) | 0.544 |
| ZNF776 | CPNE4 | ENSP00000321812 | ENSP00000478878 | Zinc finger protein 776; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Copine-4; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes; Belongs to the copine family | 0.472 |
| ZNF776 | DYRK4 | ENSP00000321812 | ENSP00000441755 | Zinc finger protein 776; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Dual specificity tyrosine-phosphorylation-regulated kinase 4; Possible non-essential role in spermiogenesis; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily | 0.499 |
| ZNF776 | FERD3L | ENSP00000321812 | ENSP00000275461 | Zinc finger protein 776; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Fer3-like protein; Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins (By similarity); Basic helix-loop-helix proteins | 0.478 |
| ZNF776 | NSUN4 | ENSP00000321812 | ENSP00000419740 | Zinc finger protein 776; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 5-methylcytosine rRNA methyltransferase NSUN4; Involved in mitochondrial ribosome assembly. 5- methylcytosine rRNA methyltransferase that probably is involved in mitochondrial ribosome small subunit (SSU) maturation by methylation of mitochondrial 12S rRNA; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled. In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4; [...] | 0.471 |
| ZNF776 | SSBP2 | ENSP00000321812 | ENSP00000483921 | Zinc finger protein 776; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Single stranded DNA binding protein 2 | 0.404 |
| ZNF776 | TMEM219 | ENSP00000321812 | ENSP00000457492 | Zinc finger protein 776; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Insulin-like growth factor-binding protein 3 receptor; Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding | 0.516 |
| ZNF776 | TRIM28 | ENSP00000321812 | ENSP00000253024 | Zinc finger protein 776; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.903 |
