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STRINGSTRING
C5orf45 C5orf45 SRSF12 SRSF12 SLC35G1 SLC35G1 GABRR2 GABRR2 ANKFN1 ANKFN1 TMEM200A TMEM200A ARHGAP35 ARHGAP35 C2CD2 C2CD2 KRT32 KRT32 OR8K3 OR8K3 RIMS3 RIMS3
"ANKFN1" - Ankyrin repeat and fibronectin type III domain containing 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ANKFN1Ankyrin repeat and fibronectin type III domain containing 1 (763 aa)    
Predicted Functional Partners:
SRSF12
Serine/arginine-rich splicing factor 12; Splicing factor that seems to antagonize SR proteins in pre-mRNA splicing regulation; RNA binding motif containing (261 aa)
            
  0.705
OR8K3
Olfactory receptor 8K3; Odorant receptor; Olfactory receptors, family 8 (312 aa)
            
  0.693
RIMS3
Regulating synaptic membrane exocytosis protein 3; Regulates synaptic membrane exocytosis (308 aa)
      
   
  0.665
C2CD2
C2 calcium dependent domain containing 2 (696 aa)
            
  0.643
KRT32
Keratin, type I cuticular Ha2; Keratins, type I; Belongs to the intermediate filament family (448 aa)
            
  0.587
GABRR2
Gamma-aminobutyric acid receptor subunit rho-2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR2 sub-subfamily (465 aa)
        
 
  0.577
TMEM200A
Transmembrane protein 200A; Belongs to the TMEM200 family (491 aa)
            
  0.577
SLC35G1
Solute carrier family 35 member G1; May play a role in intracellular calcium sensing and homeostasis. May act as a negative regulator of plasma membrane calcium-transporting ATPases preventing calcium efflux from the cell; Solute carriers (365 aa)
            
  0.572
C5orf45
MRN complex-interacting protein; Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex. Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair (343 aa)
            
  0.556
ARHGAP35
Rho GTPase-activating protein 35; Rho GTPase-activating protein (GAP), binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA. Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase- activating protein (GAP) (By simila [...] (1499 aa)
            
  0.554
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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