• Version:
  • 11.0 [archived version]
STRINGSTRING
SEMA4B SEMA4B LRRC43 LRRC43 LRRC32 LRRC32 CEP68 CEP68 BAMBI BAMBI ESAM ESAM DCBLD2 DCBLD2 ANTXR2 ANTXR2 RPP25 RPP25 PLVAP PLVAP EGFR EGFR
"DCBLD2" - Discoidin, CUB and LCCL domain containing 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DCBLD2Discoidin, CUB and LCCL domain containing 2 (775 aa)    
Predicted Functional Partners:
SEMA4B
Semaphorin-4B; Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons; Semaphorins (837 aa)
        
 
  0.767
LRRC32
Leucine-rich repeat-containing protein 32; Leucine rich repeat containing 32 (662 aa)
            
  0.766
ESAM
Endothelial cell-selective adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction; IgCAM CXADR-related subfamily (390 aa)
            
  0.745
EGFR
Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates [...] (1210 aa)
      
 
  0.688
LRRC43
Leucine-rich repeat-containing protein 43; Leucine rich repeat containing 43 (656 aa)
            
  0.642
RPP25
Ribonuclease P protein subunit p25; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. Also a component of RNase MRP. This subunit binds to RNA (199 aa)
            
  0.638
BAMBI
BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling; Belongs to the BAMBI family (260 aa)
            
  0.630
ANTXR2
Anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix (489 aa)
            
  0.607
PLVAP
Plasmalemma vesicle-associated protein; Involved in the formation of stomatal and fenestral diaphragms of caveolae. May function in microvascular permeability (442 aa)
            
  0.577
CEP68
Centrosomal protein of 68 kDa; Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase (757 aa)
            
  0.556
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (0%) [HD]
STRING is part of the ELIXIR infrastructure: it is one of ELIXIR's Core Data Resources.  Learn more >