• Version:
  • 11.0 [archived version]
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SEC14L5 SEC14L5 OAT OAT MPI MPI ESD ESD TIA1 TIA1 SLC35F6 SLC35F6 PITPNB PITPNB SEC14L2 SEC14L2 SEC14L6 SEC14L6 SEC14L3 SEC14L3 ADK ADK
"PITPNB" - Phosphatidylinositol transfer protein beta isoform in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
PITPNBPhosphatidylinositol transfer protein beta isoform; Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes; Phosphatidylinositol transfer proteins (272 aa)    
Predicted Functional Partners:
OAT
Ornithine aminotransferase, mitochondrial; Ornithine aminotransferase (439 aa)
       
 
  0.822
TIA1
Nucleolysin TIA-1 isoform p40; Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3’ untranslated regions (3’ UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis (386 aa)
     
      0.812
MPI
Mannose-6-phosphate isomerase; Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions; Belongs to the mannose-6-phosphate isomerase type 1 family (423 aa)
     
      0.810
SEC14L6
Putative SEC14-like protein 6; SEC14 like lipid binding 6 (397 aa)
     
 
  0.705
ESD
S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde (282 aa)
     
 
  0.704
ADK
Adenosine kinase; ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides; Belongs to the carbohydrate kinase PfkB family (362 aa)
     
 
  0.683
SEC14L3
SEC14-like protein 3; Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids; SEC14 family (400 aa)
     
 
  0.673
SEC14L2
SEC14-like protein 2; Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell; SEC14 family (403 aa)
     
 
  0.647
SLC35F6
Solute carrier family 35 member F6; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter (371 aa)
     
   
  0.628
SEC14L5
SEC14-like protein 5; SEC14 like lipid binding 5; PRELI domain containing (696 aa)
     
 
  0.606
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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