node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AQP11 | GDPD4 | ENSP00000318770 | ENSP00000320815 | Aquaporin-11; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes | Glycerophosphodiester phosphodiesterase domain containing 4; Belongs to the glycerophosphoryl diester phosphodiesterase family | 0.659 |
AQP11 | RAB30 | ENSP00000318770 | ENSP00000435189 | Aquaporin-11; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes | Ras-related protein Rab-30; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins; RAB, member RAS oncog [...] | 0.662 |
AQP11 | RPS28 | ENSP00000318770 | ENSP00000472469 | Aquaporin-11; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes | Ribosomal protein S28; Belongs to the eukaryotic ribosomal protein eS28 family | 0.577 |
CCDC6 | GDPD4 | ENSP00000263102 | ENSP00000320815 | Coiled-coil domain containing 6 | Glycerophosphodiester phosphodiesterase domain containing 4; Belongs to the glycerophosphoryl diester phosphodiesterase family | 0.473 |
CCDC6 | MECR | ENSP00000263102 | ENSP00000263702 | Coiled-coil domain containing 6 | Enoyl-[acyl-carrier-protein] reductase, mitochondrial; Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Has a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans- 2-hexadecenoyl-CoA (C16) | 0.546 |
FAM228A | GDPD4 | ENSP00000295150 | ENSP00000320815 | Protein FAM228A; Family with sequence similarity 228 member A; Belongs to the FAM228 family | Glycerophosphodiester phosphodiesterase domain containing 4; Belongs to the glycerophosphoryl diester phosphodiesterase family | 0.557 |
GDPD4 | AQP11 | ENSP00000320815 | ENSP00000318770 | Glycerophosphodiester phosphodiesterase domain containing 4; Belongs to the glycerophosphoryl diester phosphodiesterase family | Aquaporin-11; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes | 0.659 |
GDPD4 | CCDC6 | ENSP00000320815 | ENSP00000263102 | Glycerophosphodiester phosphodiesterase domain containing 4; Belongs to the glycerophosphoryl diester phosphodiesterase family | Coiled-coil domain containing 6 | 0.473 |
GDPD4 | FAM228A | ENSP00000320815 | ENSP00000295150 | Glycerophosphodiester phosphodiesterase domain containing 4; Belongs to the glycerophosphoryl diester phosphodiesterase family | Protein FAM228A; Family with sequence similarity 228 member A; Belongs to the FAM228 family | 0.557 |
GDPD4 | KIAA1919 | ENSP00000320815 | ENSP00000357840 | Glycerophosphodiester phosphodiesterase domain containing 4; Belongs to the glycerophosphoryl diester phosphodiesterase family | Sodium-dependent glucose transporter 1; May function as a sodium-dependent glucose transporter. Potential channels for urea in the inner medulla of kidney | 0.513 |
GDPD4 | MECR | ENSP00000320815 | ENSP00000263702 | Glycerophosphodiester phosphodiesterase domain containing 4; Belongs to the glycerophosphoryl diester phosphodiesterase family | Enoyl-[acyl-carrier-protein] reductase, mitochondrial; Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Has a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans- 2-hexadecenoyl-CoA (C16) | 0.759 |
GDPD4 | NADK2 | ENSP00000320815 | ENSP00000371362 | Glycerophosphodiester phosphodiesterase domain containing 4; Belongs to the glycerophosphoryl diester phosphodiesterase family | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo | 0.473 |
GDPD4 | RAB30 | ENSP00000320815 | ENSP00000435189 | Glycerophosphodiester phosphodiesterase domain containing 4; Belongs to the glycerophosphoryl diester phosphodiesterase family | Ras-related protein Rab-30; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins; RAB, member RAS oncog [...] | 0.721 |
GDPD4 | RPS28 | ENSP00000320815 | ENSP00000472469 | Glycerophosphodiester phosphodiesterase domain containing 4; Belongs to the glycerophosphoryl diester phosphodiesterase family | Ribosomal protein S28; Belongs to the eukaryotic ribosomal protein eS28 family | 0.693 |
GDPD4 | SH3D21 | ENSP00000320815 | ENSP00000421294 | Glycerophosphodiester phosphodiesterase domain containing 4; Belongs to the glycerophosphoryl diester phosphodiesterase family | SH3 domain containing 21 | 0.527 |
GDPD4 | SLC24A4 | ENSP00000320815 | ENSP00000431840 | Glycerophosphodiester phosphodiesterase domain containing 4; Belongs to the glycerophosphoryl diester phosphodiesterase family | Sodium/potassium/calcium exchanger 4; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis (By similarity); Belongs to the Ca(2+)-cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily | 0.455 |
KIAA1919 | GDPD4 | ENSP00000357840 | ENSP00000320815 | Sodium-dependent glucose transporter 1; May function as a sodium-dependent glucose transporter. Potential channels for urea in the inner medulla of kidney | Glycerophosphodiester phosphodiesterase domain containing 4; Belongs to the glycerophosphoryl diester phosphodiesterase family | 0.513 |
KIAA1919 | SLC24A4 | ENSP00000357840 | ENSP00000431840 | Sodium-dependent glucose transporter 1; May function as a sodium-dependent glucose transporter. Potential channels for urea in the inner medulla of kidney | Sodium/potassium/calcium exchanger 4; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis (By similarity); Belongs to the Ca(2+)-cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily | 0.428 |
MECR | CCDC6 | ENSP00000263702 | ENSP00000263102 | Enoyl-[acyl-carrier-protein] reductase, mitochondrial; Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Has a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans- 2-hexadecenoyl-CoA (C16) | Coiled-coil domain containing 6 | 0.546 |
MECR | GDPD4 | ENSP00000263702 | ENSP00000320815 | Enoyl-[acyl-carrier-protein] reductase, mitochondrial; Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Has a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans- 2-hexadecenoyl-CoA (C16) | Glycerophosphodiester phosphodiesterase domain containing 4; Belongs to the glycerophosphoryl diester phosphodiesterase family | 0.759 |