DNAJC25 protein (human) - STRING database

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DNAJC25

DnaJ heat shock protein family member C25; Belongs to the DNAJC25 family (360 aa)

Predicted Functional Partners:

DNAJC12

0.729

DNAJC9

0.704

DNAJC15

0.701

DNAJC8

0.664

DNAJC28

0.649

DNAJC17

0.630

DNAJC21

0.628

DNAJC22

0.624

DNAJC4

0.620

DNAJC24

0.619

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DNAJC12	DNAJC15	ENSP00000225171	ENSP00000368523	DnaJ heat shock protein family member C12	DnaJ homolog subfamily C member 15; Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9; DNAJ heat shock proteins	0.575
DNAJC12	DNAJC21	ENSP00000225171	ENSP00000371451	DnaJ heat shock protein family member C12	DnaJ homolog subfamily C member 21; May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA; DNAJ heat shock proteins	0.649
DNAJC12	DNAJC22	ENSP00000225171	ENSP00000446830	DnaJ heat shock protein family member C12	DnaJ homolog subfamily C member 22; May function as a co-chaperone; DNAJ heat shock proteins	0.561
DNAJC12	DNAJC24	ENSP00000225171	ENSP00000417548	DnaJ heat shock protein family member C12	DnaJ homolog subfamily C member 24; Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron- bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta); Belongs to the DPH4 family	0.629
DNAJC12	DNAJC25	ENSP00000225171	ENSP00000320650	DnaJ heat shock protein family member C12	DnaJ heat shock protein family member C25; Belongs to the DNAJC25 family	0.729
DNAJC12	DNAJC28	ENSP00000225171	ENSP00000479716	DnaJ heat shock protein family member C12	DnaJ homolog subfamily C member 28; May have a role in protein folding or as a chaperone; DNAJ heat shock proteins	0.587
DNAJC12	DNAJC8	ENSP00000225171	ENSP00000263697	DnaJ heat shock protein family member C12	DnaJ homolog subfamily C member 8; Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells; DNAJ heat shock proteins	0.740
DNAJC12	DNAJC9	ENSP00000225171	ENSP00000362041	DnaJ heat shock protein family member C12	DnaJ homolog subfamily C member 9; May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8; DNAJ heat shock proteins	0.590
DNAJC15	DNAJC12	ENSP00000368523	ENSP00000225171	DnaJ homolog subfamily C member 15; Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9; DNAJ heat shock proteins	DnaJ heat shock protein family member C12	0.575
DNAJC15	DNAJC17	ENSP00000368523	ENSP00000220496	DnaJ homolog subfamily C member 15; Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9; DNAJ heat shock proteins	DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription; DNAJ heat shock proteins	0.581
DNAJC15	DNAJC21	ENSP00000368523	ENSP00000371451	DnaJ homolog subfamily C member 15; Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9; DNAJ heat shock proteins	DnaJ homolog subfamily C member 21; May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA; DNAJ heat shock proteins	0.578
DNAJC15	DNAJC22	ENSP00000368523	ENSP00000446830	DnaJ homolog subfamily C member 15; Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9; DNAJ heat shock proteins	DnaJ homolog subfamily C member 22; May function as a co-chaperone; DNAJ heat shock proteins	0.577
DNAJC15	DNAJC24	ENSP00000368523	ENSP00000417548	DnaJ homolog subfamily C member 15; Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9; DNAJ heat shock proteins	DnaJ homolog subfamily C member 24; Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron- bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta); Belongs to the DPH4 family	0.610
DNAJC15	DNAJC25	ENSP00000368523	ENSP00000320650	DnaJ homolog subfamily C member 15; Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9; DNAJ heat shock proteins	DnaJ heat shock protein family member C25; Belongs to the DNAJC25 family	0.701
DNAJC15	DNAJC28	ENSP00000368523	ENSP00000479716	DnaJ homolog subfamily C member 15; Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9; DNAJ heat shock proteins	DnaJ homolog subfamily C member 28; May have a role in protein folding or as a chaperone; DNAJ heat shock proteins	0.567
DNAJC15	DNAJC4	ENSP00000368523	ENSP00000396896	DnaJ homolog subfamily C member 15; Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9; DNAJ heat shock proteins	DnaJ heat shock protein family member C4	0.563
DNAJC15	DNAJC8	ENSP00000368523	ENSP00000263697	DnaJ homolog subfamily C member 15; Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9; DNAJ heat shock proteins	DnaJ homolog subfamily C member 8; Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells; DNAJ heat shock proteins	0.613
DNAJC15	DNAJC9	ENSP00000368523	ENSP00000362041	DnaJ homolog subfamily C member 15; Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9; DNAJ heat shock proteins	DnaJ homolog subfamily C member 9; May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8; DNAJ heat shock proteins	0.666
DNAJC17	DNAJC15	ENSP00000220496	ENSP00000368523	DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription; DNAJ heat shock proteins	DnaJ homolog subfamily C member 15; Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9; DNAJ heat shock proteins	0.581
DNAJC17	DNAJC22	ENSP00000220496	ENSP00000446830	DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription; DNAJ heat shock proteins	DnaJ homolog subfamily C member 22; May function as a co-chaperone; DNAJ heat shock proteins	0.581

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