CCDC89 protein (human) - STRING database

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CCDC89

Coiled-coil domain containing 89; Belongs to the CCDC89 family (374 aa)

Predicted Functional Partners:

PHLDA1

0.559

C1orf50

0.550

LRRC45

0.513

KIAA0232

0.509

TSPYL4

0.500

KIF14

0.473

SIPA1L3

0.454

ZDHHC23

0.449

GIP

0.444

TTLL5

0.430

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1orf50	CCDC89	ENSP00000361603	ENSP00000320649	Uncharacterized protein C1orf50; Chromosome 1 open reading frame 50	Coiled-coil domain containing 89; Belongs to the CCDC89 family	0.550
C1orf50	KIAA0232	ENSP00000361603	ENSP00000303928	Uncharacterized protein C1orf50; Chromosome 1 open reading frame 50	Uncharacterized protein KIAA0232; KIAA0232	0.522
C1orf50	SIPA1L3	ENSP00000361603	ENSP00000222345	Uncharacterized protein C1orf50; Chromosome 1 open reading frame 50	Signal-induced proliferation-associated 1-like protein 3; Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens; PDZ domain containing	0.461
C1orf50	TTLL5	ENSP00000361603	ENSP00000298832	Uncharacterized protein C1orf50; Chromosome 1 open reading frame 50	Tubulin polyglutamylase TTLL5; Polyglutamylase which preferentially modifies alpha- tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction; Tubulin tyrosine ligase family	0.441
C1orf50	ZDHHC23	ENSP00000361603	ENSP00000330485	Uncharacterized protein C1orf50; Chromosome 1 open reading frame 50	Palmitoyltransferase ZDHHC23; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane; Zinc fingers DHHC-type	0.455
CCDC89	C1orf50	ENSP00000320649	ENSP00000361603	Coiled-coil domain containing 89; Belongs to the CCDC89 family	Uncharacterized protein C1orf50; Chromosome 1 open reading frame 50	0.550
CCDC89	GIP	ENSP00000320649	ENSP00000350005	Coiled-coil domain containing 89; Belongs to the CCDC89 family	Gastric inhibitory polypeptide; Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion; Endogenous ligands	0.444
CCDC89	KIAA0232	ENSP00000320649	ENSP00000303928	Coiled-coil domain containing 89; Belongs to the CCDC89 family	Uncharacterized protein KIAA0232; KIAA0232	0.509
CCDC89	KIF14	ENSP00000320649	ENSP00000356319	Coiled-coil domain containing 89; Belongs to the CCDC89 family	Kinesin-like protein KIF14; Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis. During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively. Regulates cell growth through regulation of cell cycle progression and cytokinesis. During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic [...]	0.473
CCDC89	LRRC45	ENSP00000320649	ENSP00000306760	Coiled-coil domain containing 89; Belongs to the CCDC89 family	Leucine-rich repeat-containing protein 45; Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion	0.513
CCDC89	PHLDA1	ENSP00000320649	ENSP00000266671	Coiled-coil domain containing 89; Belongs to the CCDC89 family	Pleckstrin homology-like domain family A member 1; Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation	0.559
CCDC89	SIPA1L3	ENSP00000320649	ENSP00000222345	Coiled-coil domain containing 89; Belongs to the CCDC89 family	Signal-induced proliferation-associated 1-like protein 3; Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens; PDZ domain containing	0.454
CCDC89	TSPYL4	ENSP00000320649	ENSP00000410943	Coiled-coil domain containing 89; Belongs to the CCDC89 family	Testis-specific Y-encoded-like protein 4; TSPY like 4	0.500
CCDC89	TTLL5	ENSP00000320649	ENSP00000298832	Coiled-coil domain containing 89; Belongs to the CCDC89 family	Tubulin polyglutamylase TTLL5; Polyglutamylase which preferentially modifies alpha- tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction; Tubulin tyrosine ligase family	0.430
CCDC89	ZDHHC23	ENSP00000320649	ENSP00000330485	Coiled-coil domain containing 89; Belongs to the CCDC89 family	Palmitoyltransferase ZDHHC23; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane; Zinc fingers DHHC-type	0.449
GIP	CCDC89	ENSP00000350005	ENSP00000320649	Gastric inhibitory polypeptide; Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion; Endogenous ligands	Coiled-coil domain containing 89; Belongs to the CCDC89 family	0.444
KIAA0232	C1orf50	ENSP00000303928	ENSP00000361603	Uncharacterized protein KIAA0232; KIAA0232	Uncharacterized protein C1orf50; Chromosome 1 open reading frame 50	0.522
KIAA0232	CCDC89	ENSP00000303928	ENSP00000320649	Uncharacterized protein KIAA0232; KIAA0232	Coiled-coil domain containing 89; Belongs to the CCDC89 family	0.509
KIAA0232	SIPA1L3	ENSP00000303928	ENSP00000222345	Uncharacterized protein KIAA0232; KIAA0232	Signal-induced proliferation-associated 1-like protein 3; Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens; PDZ domain containing	0.428
KIAA0232	TTLL5	ENSP00000303928	ENSP00000298832	Uncharacterized protein KIAA0232; KIAA0232	Tubulin polyglutamylase TTLL5; Polyglutamylase which preferentially modifies alpha- tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction; Tubulin tyrosine ligase family	0.400

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