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STRINGSTRING
ZNF160 ZNF160 SQLE SQLE R3HDM4 R3HDM4 FDFT1 FDFT1 FAXDC2 FAXDC2 LSS LSS SC5D SC5D C14orf1 C14orf1 ZNF134 ZNF134 AGMO AGMO SIGMAR1 SIGMAR1
"FAXDC2" - Fatty acid hydroxylase domain containing 2 in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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FAXDC2Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family (333 aa)    
Predicted Functional Partners:
SQLE
Squalene monooxygenase; Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway; Belongs to the squalene monooxygenase family (574 aa)
   
 
  0.804
AGMO
Alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes; Fatty acid hydroxylase domain containing (445 aa)
      
 
  0.771
LSS
Lanosterol synthase; Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency; Belongs to the terpene cyclase/mutase family (732 aa)
      
 
  0.737
SC5D
Lathosterol oxidase; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol; Belongs to the sterol desaturase family (299 aa)
      
 
0.710
ZNF134
Zinc finger protein 134; May be involved in transcriptional regulation; Zinc fingers C2H2-type (427 aa)
            
  0.701
FDFT1
Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 (417 aa)
   
 
  0.696
ZNF160
Zinc finger protein 160; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family (818 aa)
            
  0.669
SIGMAR1
Sigma non-opioid intracellular receptor 1; Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. [...] (223 aa)
      
 
  0.662
C14orf1
Probable ergosterol biosynthetic protein 28; Chromosome 14 open reading frame 1; Belongs to the ERG28 family (140 aa)
      
 
  0.656
R3HDM4
R3H domain containing 4 (268 aa)
      
 
  0.610
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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