FAM3A protein (human) - STRING database

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FAM3A

Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family (244 aa)

Predicted Functional Partners:

GGT5

0.534

ATP8A1

0.528

CXorf56

0.485

PPARG

0.452

FAM50A

0.437

CA6

0.436

WBP5

0.429

CTPS2

0.422

WDR13

0.422

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP8A1	FAM3A	ENSP00000371084	ENSP00000320521	Phospholipid-transporting ATPase IA; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1-TMEM30A seems to play a role in r [...]	Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family	0.528
CA6	FAM3A	ENSP00000366654	ENSP00000320521	Carbonic anhydrase 6; Reversible hydration of carbon dioxide. Its role in saliva is unknown; Carbonic anhydrases	Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family	0.436
CTPS2	FAM3A	ENSP00000401264	ENSP00000320521	CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides	Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family	0.422
CXorf56	FAM3A	ENSP00000441786	ENSP00000320521	UPF0428 protein CXorf56; Chromosome X open reading frame 56; Spliceosomal C complex	Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family	0.485
CXorf56	WBP5	ENSP00000441786	ENSP00000361745	UPF0428 protein CXorf56; Chromosome X open reading frame 56; Spliceosomal C complex	Transcription elongation factor A protein-like 9; May be involved in transcriptional regulation	0.450
CXorf56	WDR13	ENSP00000441786	ENSP00000365919	UPF0428 protein CXorf56; Chromosome X open reading frame 56; Spliceosomal C complex	WD repeat-containing protein 13; WD repeat domain containing	0.508
FAM3A	ATP8A1	ENSP00000320521	ENSP00000371084	Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family	Phospholipid-transporting ATPase IA; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1-TMEM30A seems to play a role in r [...]	0.528
FAM3A	CA6	ENSP00000320521	ENSP00000366654	Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family	Carbonic anhydrase 6; Reversible hydration of carbon dioxide. Its role in saliva is unknown; Carbonic anhydrases	0.436
FAM3A	CTPS2	ENSP00000320521	ENSP00000401264	Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family	CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides	0.422
FAM3A	CXorf56	ENSP00000320521	ENSP00000441786	Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family	UPF0428 protein CXorf56; Chromosome X open reading frame 56; Spliceosomal C complex	0.485
FAM3A	FAM50A	ENSP00000320521	ENSP00000377225	Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family	Protein FAM50A; May be a DNA-binding protein or transcriptional factor; Spliceosomal C complex	0.437
FAM3A	GGT5	ENSP00000320521	ENSP00000381340	Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family	Glutathione hydrolase 5 proenzyme; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4); Belongs to the gamma-glutamyltransferase family	0.534
FAM3A	PPARG	ENSP00000320521	ENSP00000287820	Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.452
FAM3A	WBP5	ENSP00000320521	ENSP00000361745	Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family	Transcription elongation factor A protein-like 9; May be involved in transcriptional regulation	0.429
FAM3A	WDR13	ENSP00000320521	ENSP00000365919	Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family	WD repeat-containing protein 13; WD repeat domain containing	0.422
FAM50A	FAM3A	ENSP00000377225	ENSP00000320521	Protein FAM50A; May be a DNA-binding protein or transcriptional factor; Spliceosomal C complex	Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family	0.437
GGT5	FAM3A	ENSP00000381340	ENSP00000320521	Glutathione hydrolase 5 proenzyme; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4); Belongs to the gamma-glutamyltransferase family	Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family	0.534
PPARG	FAM3A	ENSP00000287820	ENSP00000320521	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family	0.452
WBP5	CXorf56	ENSP00000361745	ENSP00000441786	Transcription elongation factor A protein-like 9; May be involved in transcriptional regulation	UPF0428 protein CXorf56; Chromosome X open reading frame 56; Spliceosomal C complex	0.450
WBP5	FAM3A	ENSP00000361745	ENSP00000320521	Transcription elongation factor A protein-like 9; May be involved in transcriptional regulation	Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family	0.429

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