• Version:
  • 11.0 [archived version]
STRINGSTRING
LYN LYN FAM167A FAM167A SLC39A8 SLC39A8 PTPN22 PTPN22 BLK BLK BANK1 BANK1 STAT4 STAT4 PHRF1 PHRF1 IRF5 IRF5 PXK PXK ITPR2 ITPR2
"BANK1" - B-cell scaffold protein with ankyrin repeats in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
BANK1B-cell scaffold protein with ankyrin repeats; Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2; Ankyrin repeat domain containing (785 aa)    
Predicted Functional Partners:
BLK
Tyrosine-protein kinase Blk; Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis d [...] (505 aa)
     
   
  0.757
FAM167A
Protein FAM167A; Family with sequence similarity 167 member A; Belongs to the FAM167 (SEC) family (214 aa)
           
  0.706
STAT4
Signal transducer and activator of transcription 4; Carries out a dual function- signal transduction and activation of transcription. Involved in IL12 signaling; SH2 domain containing (748 aa)
     
 
  0.699
LYN
Tyrosine-protein kinase Lyn; Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down- regulation and termination. Plays an important role in the regulation of B- [...] (512 aa)
     
 
  0.692
IRF5
Interferon regulatory factor 5; Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling; Belongs to the IRF family (514 aa)
     
   
  0.687
PTPN22
Tyrosine-protein phosphatase non-receptor type 22; Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating ’Tyr-394’ residue. Dephosphorylates ZAP70 at its activating ’Tyr- 493’ residue. Dephosphorylates the immune system activator SKAP2. Positively regulates toll-like receptor (TLR)-induced type 1 interferon production. Promotes host [...] (807 aa)
     
   
  0.686
PXK
PX domain-containing protein kinase-like protein; Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity (578 aa)
           
  0.673
SLC39A8
Zinc transporter ZIP8; Acts as a manganese and zinc influx transporter. Plays a role in manganese reabsorption in the proximal tubule of the kidney and in manganese uptake into the brain; Belongs to the ZIP transporter (TC 2.A.5) family (460 aa)
           
  0.670
PHRF1
PHD and RING finger domain-containing protein 1; Protein phosphatase 1 regulatory subunits; PHD finger proteins (1649 aa)
           
  0.669
ITPR2
Inositol 1,4,5-trisphosphate receptor type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity); Cilia and flagella associated (2701 aa)
     
 
  0.659
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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