• Version:
  • 11.0 [archived version]
STRINGSTRING
CERS1 CERS1 TBX1 TBX1 GDF1 GDF1 CFC1 CFC1 TPBGL TPBGL NKX2-6 NKX2-6 TBX5 TBX5 DCST2 DCST2 GATA5 GATA5 TBX20 TBX20 TBX3 TBX3
"NKX2-6" - Homeobox protein Nkx-2.6 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NKX2-6Homeobox protein Nkx-2.6; Acts as a transcriptional activator. In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development; NKL subclass homeoboxes and pseudogenes (301 aa)    
Predicted Functional Partners:
CFC1
Cryptic protein; NODAL coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family (223 aa)
        
 
  0.722
GDF1
Growth differentiation factor 1; May mediate cell differentiation events during embryonic development; Endogenous ligands (372 aa)
        
 
  0.652
CERS1
Embryonic growth/differentiation factor 1; May mediate cell differentiation events during embryonic development; CERS class homeoboxes (372 aa)
        
 
  0.642
TBX20
T-box transcription factor TBX20; Acts as a transcriptional activator and repressor required for cardiac development and may have key roles in the maintenance of functional and structural phenotypes in adult heart; T-boxes (447 aa)
        
 
  0.609
TBX5
T-box transcription factor TBX5; DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation. Binds to the core DNA motif of NPPA promoter; T-boxes (518 aa)
        
 
  0.577
TBX1
T-box transcription factor TBX1; Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries (By similarity); T-boxes (495 aa)
        
 
  0.554
GATA5
Transcription factor GATA-5; Transcription factor required during cardiovascular development. Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity (By similarity). Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer; GATA zinc finger domain containing (397 aa)
        
 
  0.540
TPBGL
Trophoblast glycoprotein like (382 aa)
            
  0.528
DCST2
DC-STAMP domain containing 2 (773 aa)
            
  0.520
TBX3
T-box transcription factor TBX3; Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence; T-boxes (743 aa)
        
 
  0.501
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (0%) [HD]
STRING is part of the ELIXIR infrastructure: it is one of ELIXIR's Core Data Resources.  Learn more >