node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATXN1 | ATXN1L | ENSP00000244769 | ENSP00000415822 | Ataxin-1; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. In concert with CIC and ATXN1L, involved in brain development (By similarity) | Ataxin-1-like; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity) | 0.476 |
ATXN1 | BBX | ENSP00000244769 | ENSP00000319974 | Ataxin-1; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. In concert with CIC and ATXN1L, involved in brain development (By similarity) | HMG box transcription factor BBX; Transcription factor that is necessary for cell cycle progression from G1 to S phase | 0.734 |
ATXN1L | ATXN1 | ENSP00000415822 | ENSP00000244769 | Ataxin-1-like; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity) | Ataxin-1; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. In concert with CIC and ATXN1L, involved in brain development (By similarity) | 0.476 |
ATXN1L | BBX | ENSP00000415822 | ENSP00000319974 | Ataxin-1-like; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity) | HMG box transcription factor BBX; Transcription factor that is necessary for cell cycle progression from G1 to S phase | 0.734 |
BBOX1 | BBX | ENSP00000263182 | ENSP00000319974 | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family | HMG box transcription factor BBX; Transcription factor that is necessary for cell cycle progression from G1 to S phase | 0.676 |
BBX | ATXN1 | ENSP00000319974 | ENSP00000244769 | HMG box transcription factor BBX; Transcription factor that is necessary for cell cycle progression from G1 to S phase | Ataxin-1; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. In concert with CIC and ATXN1L, involved in brain development (By similarity) | 0.734 |
BBX | ATXN1L | ENSP00000319974 | ENSP00000415822 | HMG box transcription factor BBX; Transcription factor that is necessary for cell cycle progression from G1 to S phase | Ataxin-1-like; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity) | 0.734 |
BBX | BBOX1 | ENSP00000319974 | ENSP00000263182 | HMG box transcription factor BBX; Transcription factor that is necessary for cell cycle progression from G1 to S phase | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family | 0.676 |
BBX | CCDC54 | ENSP00000319974 | ENSP00000261058 | HMG box transcription factor BBX; Transcription factor that is necessary for cell cycle progression from G1 to S phase | Coiled-coil domain containing 54 | 0.623 |
BBX | CEP78 | ENSP00000319974 | ENSP00000365782 | HMG box transcription factor BBX; Transcription factor that is necessary for cell cycle progression from G1 to S phase | Centrosomal protein of 78 kDa; May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles. May play a role in cilium biogenesis | 0.576 |
BBX | IZUMO1 | ENSP00000319974 | ENSP00000327786 | HMG box transcription factor BBX; Transcription factor that is necessary for cell cycle progression from G1 to S phase | Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1-IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane ’fusogen’ | 0.548 |
BBX | PSMG2 | ENSP00000319974 | ENSP00000325919 | HMG box transcription factor BBX; Transcription factor that is necessary for cell cycle progression from G1 to S phase | Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization | 0.650 |
BBX | RSBN1 | ENSP00000319974 | ENSP00000261441 | HMG box transcription factor BBX; Transcription factor that is necessary for cell cycle progression from G1 to S phase | Lysine-specific demethylase 9; Histone demethylase that specifically demethylates dimethylated ’Lys-20’ of histone H4 (H4K20me2), thereby modulating chromosome architecture; Belongs to the round spermatid basic protein 1 family | 0.555 |
BBX | THEMIS | ENSP00000319974 | ENSP00000357231 | HMG box transcription factor BBX; Transcription factor that is necessary for cell cycle progression from G1 to S phase | Protein THEMIS; Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk; Belongs to the themis family | 0.572 |
BBX | TMEM194A | ENSP00000319974 | ENSP00000300128 | HMG box transcription factor BBX; Transcription factor that is necessary for cell cycle progression from G1 to S phase | Transmembrane protein 194A | 0.556 |
CCDC54 | BBX | ENSP00000261058 | ENSP00000319974 | Coiled-coil domain containing 54 | HMG box transcription factor BBX; Transcription factor that is necessary for cell cycle progression from G1 to S phase | 0.623 |
CCDC54 | CEP78 | ENSP00000261058 | ENSP00000365782 | Coiled-coil domain containing 54 | Centrosomal protein of 78 kDa; May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles. May play a role in cilium biogenesis | 0.745 |
CEP78 | BBX | ENSP00000365782 | ENSP00000319974 | Centrosomal protein of 78 kDa; May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles. May play a role in cilium biogenesis | HMG box transcription factor BBX; Transcription factor that is necessary for cell cycle progression from G1 to S phase | 0.576 |
CEP78 | CCDC54 | ENSP00000365782 | ENSP00000261058 | Centrosomal protein of 78 kDa; May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles. May play a role in cilium biogenesis | Coiled-coil domain containing 54 | 0.745 |
IZUMO1 | BBX | ENSP00000327786 | ENSP00000319974 | Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1-IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane ’fusogen’ | HMG box transcription factor BBX; Transcription factor that is necessary for cell cycle progression from G1 to S phase | 0.548 |