| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AUH | DNAJC19 | ENSP00000364883 | ENSP00000372005 | Methylglutaconyl-CoA hydratase, mitochondrial; Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Also has itaconyl-CoA hydratase activity by converting itaconyl-CoA into citramalyl-CoA in the C5- dicarboxylate catabolism pathway. The C5- dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5’-AUUUA-3’ motifs | Mitochondrial import inner membrane translocase subunit TIM14; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity); Belongs to the TIM14 family | 0.802 |
| AUH | OPA3 | ENSP00000364883 | ENSP00000319817 | Methylglutaconyl-CoA hydratase, mitochondrial; Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Also has itaconyl-CoA hydratase activity by converting itaconyl-CoA into citramalyl-CoA in the C5- dicarboxylate catabolism pathway. The C5- dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5’-AUUUA-3’ motifs | Optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia); OPA3, outer mitochondrial membrane lipid metabolism regulator | 0.755 |
| C8orf44 | GK5 | ENSP00000428002 | ENSP00000418001 | Putative uncharacterized protein C8orf44; Chromosome 8 open reading frame 44 | Glycerol kinase 5 | 0.733 |
| C8orf44 | ICA1L | ENSP00000428002 | ENSP00000478645 | Putative uncharacterized protein C8orf44; Chromosome 8 open reading frame 44 | Islet cell autoantigen 1-like protein; Classical BAR domain containing | 0.765 |
| C8orf44 | OPA3 | ENSP00000428002 | ENSP00000319817 | Putative uncharacterized protein C8orf44; Chromosome 8 open reading frame 44 | Optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia); OPA3, outer mitochondrial membrane lipid metabolism regulator | 0.795 |
| CISD2 | OPA3 | ENSP00000273986 | ENSP00000319817 | CDGSH iron-sulfur domain-containing protein 2; Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy; CDGSH iron sulfur domain containing | Optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia); OPA3, outer mitochondrial membrane lipid metabolism regulator | 0.735 |
| CISD2 | SFXN4 | ENSP00000273986 | ENSP00000347924 | CDGSH iron-sulfur domain-containing protein 2; Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy; CDGSH iron sulfur domain containing | Sideroflexin-4; Potential iron transporter; Belongs to the sideroflexin family | 0.716 |
| CISD2 | SPG7 | ENSP00000273986 | ENSP00000268704 | CDGSH iron-sulfur domain-containing protein 2; Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy; CDGSH iron sulfur domain containing | Paraplegin; ATP-dependent zinc metalloprotease. Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function; In the N-terminal section; belongs to the AAA ATPase family | 0.654 |
| CISD2 | TSFM | ENSP00000273986 | ENSP00000313877 | CDGSH iron-sulfur domain-containing protein 2; Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy; CDGSH iron sulfur domain containing | Elongation factor Ts, mitochondrial; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome; Belongs to the EF-Ts family | 0.666 |
| DNAJC19 | AUH | ENSP00000372005 | ENSP00000364883 | Mitochondrial import inner membrane translocase subunit TIM14; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity); Belongs to the TIM14 family | Methylglutaconyl-CoA hydratase, mitochondrial; Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Also has itaconyl-CoA hydratase activity by converting itaconyl-CoA into citramalyl-CoA in the C5- dicarboxylate catabolism pathway. The C5- dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5’-AUUUA-3’ motifs | 0.802 |
| DNAJC19 | OPA3 | ENSP00000372005 | ENSP00000319817 | Mitochondrial import inner membrane translocase subunit TIM14; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity); Belongs to the TIM14 family | Optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia); OPA3, outer mitochondrial membrane lipid metabolism regulator | 0.750 |
| GK5 | C8orf44 | ENSP00000418001 | ENSP00000428002 | Glycerol kinase 5 | Putative uncharacterized protein C8orf44; Chromosome 8 open reading frame 44 | 0.733 |
| GK5 | ICA1L | ENSP00000418001 | ENSP00000478645 | Glycerol kinase 5 | Islet cell autoantigen 1-like protein; Classical BAR domain containing | 0.734 |
| GK5 | OPA3 | ENSP00000418001 | ENSP00000319817 | Glycerol kinase 5 | Optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia); OPA3, outer mitochondrial membrane lipid metabolism regulator | 0.715 |
| ICA1L | C8orf44 | ENSP00000478645 | ENSP00000428002 | Islet cell autoantigen 1-like protein; Classical BAR domain containing | Putative uncharacterized protein C8orf44; Chromosome 8 open reading frame 44 | 0.765 |
| ICA1L | GK5 | ENSP00000478645 | ENSP00000418001 | Islet cell autoantigen 1-like protein; Classical BAR domain containing | Glycerol kinase 5 | 0.734 |
| ICA1L | OPA3 | ENSP00000478645 | ENSP00000319817 | Islet cell autoantigen 1-like protein; Classical BAR domain containing | Optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia); OPA3, outer mitochondrial membrane lipid metabolism regulator | 0.730 |
| OPA3 | AUH | ENSP00000319817 | ENSP00000364883 | Optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia); OPA3, outer mitochondrial membrane lipid metabolism regulator | Methylglutaconyl-CoA hydratase, mitochondrial; Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Also has itaconyl-CoA hydratase activity by converting itaconyl-CoA into citramalyl-CoA in the C5- dicarboxylate catabolism pathway. The C5- dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5’-AUUUA-3’ motifs | 0.755 |
| OPA3 | C8orf44 | ENSP00000319817 | ENSP00000428002 | Optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia); OPA3, outer mitochondrial membrane lipid metabolism regulator | Putative uncharacterized protein C8orf44; Chromosome 8 open reading frame 44 | 0.795 |
| OPA3 | CISD2 | ENSP00000319817 | ENSP00000273986 | Optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia); OPA3, outer mitochondrial membrane lipid metabolism regulator | CDGSH iron-sulfur domain-containing protein 2; Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy; CDGSH iron sulfur domain containing | 0.735 |
