IGDCC4 protein (human) - STRING database

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IGDCC4

Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family (1250 aa)

Predicted Functional Partners:

FAM173B

0.659

GRAMD2

0.634

NAPEPLD

0.536

TULP4

0.504

IGSF11

0.501

DNAJA1

0.499

P4HA3

0.482

LENG8

0.478

EXOSC9

0.475

C15orf39

0.473

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C15orf39	IGDCC4	ENSP00000353854	ENSP00000319623	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39	Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family	0.473
DNAJA1	IGDCC4	ENSP00000369127	ENSP00000319623	DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Plays a role in protein transport into mitochondria via its role as co- chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV; DNAJ heat shock proteins	Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family	0.499
EXOSC9	FAM173B	ENSP00000368984	ENSP00000422338	Exosome complex component RRP45; Non-catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding ’pervasive’ transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cyto [...]	Protein FAM173B; Seven-beta-strand methyltransferase motif containing; Belongs to the FAM173 family	0.576
EXOSC9	IGDCC4	ENSP00000368984	ENSP00000319623	Exosome complex component RRP45; Non-catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding ’pervasive’ transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cyto [...]	Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family	0.475
FAM173B	EXOSC9	ENSP00000422338	ENSP00000368984	Protein FAM173B; Seven-beta-strand methyltransferase motif containing; Belongs to the FAM173 family	Exosome complex component RRP45; Non-catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding ’pervasive’ transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cyto [...]	0.576
FAM173B	IGDCC4	ENSP00000422338	ENSP00000319623	Protein FAM173B; Seven-beta-strand methyltransferase motif containing; Belongs to the FAM173 family	Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family	0.659
FAM173B	TULP4	ENSP00000422338	ENSP00000356064	Protein FAM173B; Seven-beta-strand methyltransferase motif containing; Belongs to the FAM173 family	Tubby-related protein 4; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the TUB family	0.607
GRAMD2	IGDCC4	ENSP00000311657	ENSP00000319623	GRAM domain-containing protein 2A; GRAM domain containing 2	Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family	0.634
IGDCC4	C15orf39	ENSP00000319623	ENSP00000353854	Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family	Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39	0.473
IGDCC4	DNAJA1	ENSP00000319623	ENSP00000369127	Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family	DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Plays a role in protein transport into mitochondria via its role as co- chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis. Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV; DNAJ heat shock proteins	0.499
IGDCC4	EXOSC9	ENSP00000319623	ENSP00000368984	Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family	Exosome complex component RRP45; Non-catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding ’pervasive’ transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cyto [...]	0.475
IGDCC4	FAM173B	ENSP00000319623	ENSP00000422338	Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family	Protein FAM173B; Seven-beta-strand methyltransferase motif containing; Belongs to the FAM173 family	0.659
IGDCC4	GRAMD2	ENSP00000319623	ENSP00000311657	Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family	GRAM domain-containing protein 2A; GRAM domain containing 2	0.634
IGDCC4	IGSF11	ENSP00000319623	ENSP00000377370	Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family	Immunoglobulin superfamily member 11; Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth; I-set domain containing	0.501
IGDCC4	LENG8	ENSP00000319623	ENSP00000318374	Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family	Leukocyte receptor cluster member 8	0.478
IGDCC4	NAPEPLD	ENSP00000319623	ENSP00000407112	Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family	N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D; Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the generation of anandamide (N- arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors (By similarity)	0.536
IGDCC4	P4HA3	ENSP00000319623	ENSP00000401749	Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family	Prolyl 4-hydroxylase subunit alpha-3; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family	0.482
IGDCC4	TULP4	ENSP00000319623	ENSP00000356064	Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family	Tubby-related protein 4; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the TUB family	0.504
IGSF11	IGDCC4	ENSP00000377370	ENSP00000319623	Immunoglobulin superfamily member 11; Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth; I-set domain containing	Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family	0.501
LENG8	IGDCC4	ENSP00000318374	ENSP00000319623	Leukocyte receptor cluster member 8	Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family	0.478

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