node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATE1 | KIAA0196 | ENSP00000224652 | ENSP00000318016 | Arginyl-tRNA--protein transferase 1; Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity) | WASH complex subunit 5; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting. May be involved in axonal outgrowth. Involved in cellular localization of ADRB2. Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 | 0.489 |
ATE1 | ZNF572 | ENSP00000224652 | ENSP00000319305 | Arginyl-tRNA--protein transferase 1; Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity) | Zinc finger protein 572; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.521 |
FAM19A5 | RMDN2 | ENSP00000383933 | ENSP00000234195 | Protein FAM19A5; Family with sequence similarity 19 member A5, C-C motif chemokine like; Belongs to the FAM19/TAFA family | Regulator of microtubule dynamics 2; Belongs to the RMDN family | 0.520 |
FAM19A5 | ZDHHC19 | ENSP00000383933 | ENSP00000296326 | Protein FAM19A5; Family with sequence similarity 19 member A5, C-C motif chemokine like; Belongs to the FAM19/TAFA family | Probable palmitoyltransferase ZDHHC19; Zinc finger DHHC-type containing 19; Belongs to the DHHC palmitoyltransferase family | 0.473 |
FAM19A5 | ZNF572 | ENSP00000383933 | ENSP00000319305 | Protein FAM19A5; Family with sequence similarity 19 member A5, C-C motif chemokine like; Belongs to the FAM19/TAFA family | Zinc finger protein 572; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.513 |
FAM84B | KIAA0196 | ENSP00000302578 | ENSP00000318016 | Protein FAM84B; Family with sequence similarity 84 member B; Belongs to the FAM84 family | WASH complex subunit 5; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting. May be involved in axonal outgrowth. Involved in cellular localization of ADRB2. Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 | 0.516 |
FAM84B | POU5F1B | ENSP00000302578 | ENSP00000419298 | Protein FAM84B; Family with sequence similarity 84 member B; Belongs to the FAM84 family | Putative POU domain, class 5, transcription factor 1B; Shows weak transcriptional activator activity; POU class homeoboxes and pseudogenes | 0.586 |
FAM84B | TRIB1 | ENSP00000302578 | ENSP00000312150 | Protein FAM84B; Family with sequence similarity 84 member B; Belongs to the FAM84 family | Tribbles homolog 1; Adapter protein involved in protein degradation by interacting with RFWD2/COP1 ubiquitin ligase. The RFWD2-binding motif is masked by autoinhibitory interactions with the protein kinase domain. Serves to alter RFWD2 substrate specificity by directing the activity of RFWD2 toward CEBPA. Binds selectively the recognition sequence of CEBPA. Regulates myeloid cell differentiation by altering the expression of CEBPA in a RFWD2- dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Int [...] | 0.412 |
FAM84B | ZNF572 | ENSP00000302578 | ENSP00000319305 | Protein FAM84B; Family with sequence similarity 84 member B; Belongs to the FAM84 family | Zinc finger protein 572; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.575 |
KIAA0196 | ATE1 | ENSP00000318016 | ENSP00000224652 | WASH complex subunit 5; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting. May be involved in axonal outgrowth. Involved in cellular localization of ADRB2. Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 | Arginyl-tRNA--protein transferase 1; Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity) | 0.489 |
KIAA0196 | FAM84B | ENSP00000318016 | ENSP00000302578 | WASH complex subunit 5; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting. May be involved in axonal outgrowth. Involved in cellular localization of ADRB2. Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 | Protein FAM84B; Family with sequence similarity 84 member B; Belongs to the FAM84 family | 0.516 |
KIAA0196 | NSMCE2 | ENSP00000318016 | ENSP00000287437 | WASH complex subunit 5; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting. May be involved in axonal outgrowth. Involved in cellular localization of ADRB2. Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 | E3 SUMO-protein ligase NSE2; E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin com [...] | 0.571 |
KIAA0196 | ZNF572 | ENSP00000318016 | ENSP00000319305 | WASH complex subunit 5; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting. May be involved in axonal outgrowth. Involved in cellular localization of ADRB2. Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 | Zinc finger protein 572; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.647 |
NSMCE2 | KIAA0196 | ENSP00000287437 | ENSP00000318016 | E3 SUMO-protein ligase NSE2; E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin com [...] | WASH complex subunit 5; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting. May be involved in axonal outgrowth. Involved in cellular localization of ADRB2. Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 | 0.571 |
NSMCE2 | TRIB1 | ENSP00000287437 | ENSP00000312150 | E3 SUMO-protein ligase NSE2; E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin com [...] | Tribbles homolog 1; Adapter protein involved in protein degradation by interacting with RFWD2/COP1 ubiquitin ligase. The RFWD2-binding motif is masked by autoinhibitory interactions with the protein kinase domain. Serves to alter RFWD2 substrate specificity by directing the activity of RFWD2 toward CEBPA. Binds selectively the recognition sequence of CEBPA. Regulates myeloid cell differentiation by altering the expression of CEBPA in a RFWD2- dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Int [...] | 0.408 |
NSMCE2 | ZNF572 | ENSP00000287437 | ENSP00000319305 | E3 SUMO-protein ligase NSE2; E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin com [...] | Zinc finger protein 572; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.559 |
POU5F1B | FAM84B | ENSP00000419298 | ENSP00000302578 | Putative POU domain, class 5, transcription factor 1B; Shows weak transcriptional activator activity; POU class homeoboxes and pseudogenes | Protein FAM84B; Family with sequence similarity 84 member B; Belongs to the FAM84 family | 0.586 |
POU5F1B | ZNF572 | ENSP00000419298 | ENSP00000319305 | Putative POU domain, class 5, transcription factor 1B; Shows weak transcriptional activator activity; POU class homeoboxes and pseudogenes | Zinc finger protein 572; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.495 |
RMDN2 | FAM19A5 | ENSP00000234195 | ENSP00000383933 | Regulator of microtubule dynamics 2; Belongs to the RMDN family | Protein FAM19A5; Family with sequence similarity 19 member A5, C-C motif chemokine like; Belongs to the FAM19/TAFA family | 0.520 |
RMDN2 | ZDHHC19 | ENSP00000234195 | ENSP00000296326 | Regulator of microtubule dynamics 2; Belongs to the RMDN family | Probable palmitoyltransferase ZDHHC19; Zinc finger DHHC-type containing 19; Belongs to the DHHC palmitoyltransferase family | 0.695 |