GPR62 protein (human) - STRING database

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GPR62

Probable G-protein coupled receptor 62; Orphan receptor; G protein-coupled receptors, Class A orphans (368 aa)

Predicted Functional Partners:

GPER1

0.885

GPR45

0.657

GPR135

0.640

OPALIN

0.630

GPR162

0.604

GPR101

0.602

GPR25

0.598

ERMN

0.585

GPR26

0.576

GPR52

0.570

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ERMN	GPR62	ENSP00000380453	ENSP00000319250	Ermin; Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity)	Probable G-protein coupled receptor 62; Orphan receptor; G protein-coupled receptors, Class A orphans	0.585
ERMN	OPALIN	ENSP00000380453	ENSP00000360214	Ermin; Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity)	Opalin; Oligodendrocytic myelin paranodal and inner loop protein	0.820
GPER1	GPR62	ENSP00000380281	ENSP00000319250	G-protein coupled estrogen receptor 1; G-protein coupled estrogen receptor that binds to 17- beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine [...]	Probable G-protein coupled receptor 62; Orphan receptor; G protein-coupled receptors, Class A orphans	0.885
GPR101	GPR162	ENSP00000298110	ENSP00000311528	Probable G-protein coupled receptor 101; Orphan receptor; G protein-coupled receptors, Class A orphans	Probable G-protein coupled receptor 162; Orphan receptor; G protein-coupled receptors, Class A orphans	0.595
GPR101	GPR26	ENSP00000298110	ENSP00000284674	Probable G-protein coupled receptor 101; Orphan receptor; G protein-coupled receptors, Class A orphans	G-protein coupled receptor 26; Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP; G protein-coupled receptors, Class A orphans	0.565
GPR101	GPR62	ENSP00000298110	ENSP00000319250	Probable G-protein coupled receptor 101; Orphan receptor; G protein-coupled receptors, Class A orphans	Probable G-protein coupled receptor 62; Orphan receptor; G protein-coupled receptors, Class A orphans	0.602
GPR135	GPR162	ENSP00000378548	ENSP00000311528	Probable G-protein coupled receptor 135; Orphan receptor; G protein-coupled receptors, Class A orphans	Probable G-protein coupled receptor 162; Orphan receptor; G protein-coupled receptors, Class A orphans	0.609
GPR135	GPR25	ENSP00000378548	ENSP00000301917	Probable G-protein coupled receptor 135; Orphan receptor; G protein-coupled receptors, Class A orphans	Probable G-protein coupled receptor 25; Orphan receptor; G protein-coupled receptors, Class A orphans	0.628
GPR135	GPR26	ENSP00000378548	ENSP00000284674	Probable G-protein coupled receptor 135; Orphan receptor; G protein-coupled receptors, Class A orphans	G-protein coupled receptor 26; Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP; G protein-coupled receptors, Class A orphans	0.428
GPR135	GPR62	ENSP00000378548	ENSP00000319250	Probable G-protein coupled receptor 135; Orphan receptor; G protein-coupled receptors, Class A orphans	Probable G-protein coupled receptor 62; Orphan receptor; G protein-coupled receptors, Class A orphans	0.640
GPR162	GPR101	ENSP00000311528	ENSP00000298110	Probable G-protein coupled receptor 162; Orphan receptor; G protein-coupled receptors, Class A orphans	Probable G-protein coupled receptor 101; Orphan receptor; G protein-coupled receptors, Class A orphans	0.595
GPR162	GPR135	ENSP00000311528	ENSP00000378548	Probable G-protein coupled receptor 162; Orphan receptor; G protein-coupled receptors, Class A orphans	Probable G-protein coupled receptor 135; Orphan receptor; G protein-coupled receptors, Class A orphans	0.609
GPR162	GPR25	ENSP00000311528	ENSP00000301917	Probable G-protein coupled receptor 162; Orphan receptor; G protein-coupled receptors, Class A orphans	Probable G-protein coupled receptor 25; Orphan receptor; G protein-coupled receptors, Class A orphans	0.508
GPR162	GPR26	ENSP00000311528	ENSP00000284674	Probable G-protein coupled receptor 162; Orphan receptor; G protein-coupled receptors, Class A orphans	G-protein coupled receptor 26; Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP; G protein-coupled receptors, Class A orphans	0.554
GPR162	GPR52	ENSP00000311528	ENSP00000356658	Probable G-protein coupled receptor 162; Orphan receptor; G protein-coupled receptors, Class A orphans	G-protein coupled receptor 52; Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization. May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum. Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation; G protein-coupled [...]	0.580
GPR162	GPR62	ENSP00000311528	ENSP00000319250	Probable G-protein coupled receptor 162; Orphan receptor; G protein-coupled receptors, Class A orphans	Probable G-protein coupled receptor 62; Orphan receptor; G protein-coupled receptors, Class A orphans	0.604
GPR25	GPR135	ENSP00000301917	ENSP00000378548	Probable G-protein coupled receptor 25; Orphan receptor; G protein-coupled receptors, Class A orphans	Probable G-protein coupled receptor 135; Orphan receptor; G protein-coupled receptors, Class A orphans	0.628
GPR25	GPR162	ENSP00000301917	ENSP00000311528	Probable G-protein coupled receptor 25; Orphan receptor; G protein-coupled receptors, Class A orphans	Probable G-protein coupled receptor 162; Orphan receptor; G protein-coupled receptors, Class A orphans	0.508
GPR25	GPR45	ENSP00000301917	ENSP00000258456	Probable G-protein coupled receptor 25; Orphan receptor; G protein-coupled receptors, Class A orphans	Probable G-protein coupled receptor 45; Orphan receptor. May play a role in brain function; G protein-coupled receptors, Class A orphans	0.916
GPR25	GPR52	ENSP00000301917	ENSP00000356658	Probable G-protein coupled receptor 25; Orphan receptor; G protein-coupled receptors, Class A orphans	G-protein coupled receptor 52; Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization. May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum. Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation; G protein-coupled [...]	0.491

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