| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCP110 | CEP290 | ENSP00000370803 | ENSP00000448012 | Centriolar coiled-coil protein of 110 kDa; Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and geno [...] | Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. Required for the correct localization of ciliary and phototransduction proteins in retinal photorecepto [...] | 0.997 |
| CCP110 | CETN1 | ENSP00000370803 | ENSP00000319052 | Centriolar coiled-coil protein of 110 kDa; Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and geno [...] | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function; EF-hand domain containing | 0.727 |
| CCP110 | PCM1 | ENSP00000370803 | ENSP00000327077 | Centriolar coiled-coil protein of 110 kDa; Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and geno [...] | Pericentriolar material 1 protein; Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Involved in the biogenesis of cilia; Belongs to the PCM1 family | 0.940 |
| CCP110 | POC5 | ENSP00000370803 | ENSP00000410216 | Centriolar coiled-coil protein of 110 kDa; Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and geno [...] | Centrosomal protein POC5; Essential for the assembly of the distal half of centrioles, required for centriole elongation; Belongs to the POC5 family | 0.728 |
| CCP110 | SFI1 | ENSP00000370803 | ENSP00000383145 | Centriolar coiled-coil protein of 110 kDa; Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and geno [...] | Protein SFI1 homolog; Plays a role in the dynamic structure of centrosome- associated contractile fibers via its interaction with CETN2; Belongs to the SFI1 family | 0.939 |
| CEP290 | CCP110 | ENSP00000448012 | ENSP00000370803 | Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. Required for the correct localization of ciliary and phototransduction proteins in retinal photorecepto [...] | Centriolar coiled-coil protein of 110 kDa; Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and geno [...] | 0.997 |
| CEP290 | CETN1 | ENSP00000448012 | ENSP00000319052 | Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. Required for the correct localization of ciliary and phototransduction proteins in retinal photorecepto [...] | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function; EF-hand domain containing | 0.697 |
| CEP290 | PCM1 | ENSP00000448012 | ENSP00000327077 | Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. Required for the correct localization of ciliary and phototransduction proteins in retinal photorecepto [...] | Pericentriolar material 1 protein; Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Involved in the biogenesis of cilia; Belongs to the PCM1 family | 0.978 |
| CEP290 | SFI1 | ENSP00000448012 | ENSP00000383145 | Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. Required for the correct localization of ciliary and phototransduction proteins in retinal photorecepto [...] | Protein SFI1 homolog; Plays a role in the dynamic structure of centrosome- associated contractile fibers via its interaction with CETN2; Belongs to the SFI1 family | 0.900 |
| CETN1 | CCP110 | ENSP00000319052 | ENSP00000370803 | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function; EF-hand domain containing | Centriolar coiled-coil protein of 110 kDa; Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and geno [...] | 0.727 |
| CETN1 | CEP290 | ENSP00000319052 | ENSP00000448012 | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function; EF-hand domain containing | Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. Required for the correct localization of ciliary and phototransduction proteins in retinal photorecepto [...] | 0.697 |
| CETN1 | LELP1 | ENSP00000319052 | ENSP00000357736 | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function; EF-hand domain containing | Late cornified envelope like proline rich 1; Belongs to the cornifin (SPRR) family | 0.681 |
| CETN1 | MCM3AP | ENSP00000319052 | ENSP00000380820 | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function; EF-hand domain containing | Germinal-center associated nuclear protein; Isoform GANP- Essential for the generation of high- affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation- dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells (By similarity). Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein p [...] | 0.839 |
| CETN1 | MORN1 | ENSP00000319052 | ENSP00000367792 | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function; EF-hand domain containing | MORN repeat containing 1 | 0.681 |
| CETN1 | PCM1 | ENSP00000319052 | ENSP00000327077 | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function; EF-hand domain containing | Pericentriolar material 1 protein; Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Involved in the biogenesis of cilia; Belongs to the PCM1 family | 0.681 |
| CETN1 | POC5 | ENSP00000319052 | ENSP00000410216 | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function; EF-hand domain containing | Centrosomal protein POC5; Essential for the assembly of the distal half of centrioles, required for centriole elongation; Belongs to the POC5 family | 0.673 |
| CETN1 | SAC3D1 | ENSP00000319052 | ENSP00000381824 | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function; EF-hand domain containing | SAC3 domain-containing protein 1; Involved in centrosome duplication and mitotic progression; Belongs to the SAC3 family | 0.786 |
| CETN1 | SFI1 | ENSP00000319052 | ENSP00000383145 | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function; EF-hand domain containing | Protein SFI1 homolog; Plays a role in the dynamic structure of centrosome- associated contractile fibers via its interaction with CETN2; Belongs to the SFI1 family | 0.925 |
| CETN1 | XPC | ENSP00000319052 | ENSP00000285021 | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function; EF-hand domain containing | DNA repair protein complementing XP-C cells; Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function- XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures int [...] | 0.760 |
| LELP1 | CETN1 | ENSP00000357736 | ENSP00000319052 | Late cornified envelope like proline rich 1; Belongs to the cornifin (SPRR) family | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function; EF-hand domain containing | 0.681 |
