SOBP protein (human) - STRING database

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SOBP

Sine oculis-binding protein homolog; Implicated in development of the cochlea (873 aa)

Predicted Functional Partners:

PACSIN1

0.730

FAXC

0.706

CCDC85C

0.700

METTL24

0.689

SIMC1

0.644

MMS22L

0.643

ZMYM4

0.557

MDC1

0.555

C6orf203

0.553

DDX43

0.529

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C6orf203	SOBP	ENSP00000384867	ENSP00000318900	Uncharacterized protein C6orf203; Chromosome 6 open reading frame 203	Sine oculis-binding protein homolog; Implicated in development of the cochlea	0.553
CCDC85C	DDX43	ENSP00000369592	ENSP00000359361	Coiled-coil domain-containing protein 85C; May play an important role in cortical development, especially in the maintenance of radial glia	Probable ATP-dependent RNA helicase DDX43; DEAD-box helicase 43	0.480
CCDC85C	SOBP	ENSP00000369592	ENSP00000318900	Coiled-coil domain-containing protein 85C; May play an important role in cortical development, especially in the maintenance of radial glia	Sine oculis-binding protein homolog; Implicated in development of the cochlea	0.700
DDX43	CCDC85C	ENSP00000359361	ENSP00000369592	Probable ATP-dependent RNA helicase DDX43; DEAD-box helicase 43	Coiled-coil domain-containing protein 85C; May play an important role in cortical development, especially in the maintenance of radial glia	0.480
DDX43	SOBP	ENSP00000359361	ENSP00000318900	Probable ATP-dependent RNA helicase DDX43; DEAD-box helicase 43	Sine oculis-binding protein homolog; Implicated in development of the cochlea	0.529
FAXC	MMS22L	ENSP00000374328	ENSP00000275053	Failed axon connections homolog; May play a role in axonal development	Protein MMS22-like; Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork- associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA	0.693
FAXC	SOBP	ENSP00000374328	ENSP00000318900	Failed axon connections homolog; May play a role in axonal development	Sine oculis-binding protein homolog; Implicated in development of the cochlea	0.706
MDC1	SOBP	ENSP00000365588	ENSP00000318900	Mediator of DNA damage checkpoint protein 1; Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by ’Ser-139’ phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be a [...]	Sine oculis-binding protein homolog; Implicated in development of the cochlea	0.555
METTL24	SOBP	ENSP00000344071	ENSP00000318900	Methyltransferase-like protein 24; Methyltransferase like 24	Sine oculis-binding protein homolog; Implicated in development of the cochlea	0.689
MMS22L	FAXC	ENSP00000275053	ENSP00000374328	Protein MMS22-like; Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork- associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA	Failed axon connections homolog; May play a role in axonal development	0.693
MMS22L	SOBP	ENSP00000275053	ENSP00000318900	Protein MMS22-like; Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork- associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA	Sine oculis-binding protein homolog; Implicated in development of the cochlea	0.643
PACSIN1	SOBP	ENSP00000484060	ENSP00000318900	Protein kinase C and casein kinase substrate in neurons protein 1; Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching [...]	Sine oculis-binding protein homolog; Implicated in development of the cochlea	0.730
SIMC1	SOBP	ENSP00000342075	ENSP00000318900	SUMO-interacting motif-containing protein 1; SUMO interacting motifs containing 1	Sine oculis-binding protein homolog; Implicated in development of the cochlea	0.644
SOBP	C6orf203	ENSP00000318900	ENSP00000384867	Sine oculis-binding protein homolog; Implicated in development of the cochlea	Uncharacterized protein C6orf203; Chromosome 6 open reading frame 203	0.553
SOBP	CCDC85C	ENSP00000318900	ENSP00000369592	Sine oculis-binding protein homolog; Implicated in development of the cochlea	Coiled-coil domain-containing protein 85C; May play an important role in cortical development, especially in the maintenance of radial glia	0.700
SOBP	DDX43	ENSP00000318900	ENSP00000359361	Sine oculis-binding protein homolog; Implicated in development of the cochlea	Probable ATP-dependent RNA helicase DDX43; DEAD-box helicase 43	0.529
SOBP	FAXC	ENSP00000318900	ENSP00000374328	Sine oculis-binding protein homolog; Implicated in development of the cochlea	Failed axon connections homolog; May play a role in axonal development	0.706
SOBP	MDC1	ENSP00000318900	ENSP00000365588	Sine oculis-binding protein homolog; Implicated in development of the cochlea	Mediator of DNA damage checkpoint protein 1; Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by ’Ser-139’ phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be a [...]	0.555
SOBP	METTL24	ENSP00000318900	ENSP00000344071	Sine oculis-binding protein homolog; Implicated in development of the cochlea	Methyltransferase-like protein 24; Methyltransferase like 24	0.689
SOBP	MMS22L	ENSP00000318900	ENSP00000275053	Sine oculis-binding protein homolog; Implicated in development of the cochlea	Protein MMS22-like; Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork- associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA	0.643

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