SHMT1 protein (human) - STRING database

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Score

SHMT1

Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine (483 aa)

Predicted Functional Partners:

GART

0.997

ATIC

0.995

MTHFD2

0.991

MTHFD1

0.991

GLDC

0.990

MTHFD2L

0.990

TYMS

0.988

AMT

0.988

MTHFR

0.988

MTHFD1L

0.983

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMT	ATIC	ENSP00000273588	ENSP00000236959	Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine	Bifunctional purine biosynthesis protein PURH; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family	0.962
AMT	GART	ENSP00000273588	ENSP00000371253	Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine	Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family	0.952
AMT	GLDC	ENSP00000273588	ENSP00000370737	Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine	Glycine dehydrogenase (decarboxylating), mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH)	0.999
AMT	MTHFD1	ENSP00000273588	ENSP00000216605	Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine	C-1-tetrahydrofolate synthase, cytoplasmic; Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1; In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family	0.969
AMT	MTHFD1L	ENSP00000273588	ENSP00000478253	Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine	Monofunctional C1-tetrahydrofolate synthase, mitochondrial; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2; In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family	0.965
AMT	MTHFD2	ENSP00000273588	ENSP00000377617	Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency; Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family	0.979
AMT	MTHFD2L	ENSP00000273588	ENSP00000379108	Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine	Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2; Methylenetetrahydrofolate dehydrogenase 2 like	0.976
AMT	MTHFR	ENSP00000273588	ENSP00000365777	Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine	Methylenetetrahydrofolate reductase; Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine	0.959
AMT	SHMT1	ENSP00000273588	ENSP00000318868	Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine	Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine	0.988
AMT	TYMS	ENSP00000273588	ENSP00000315644	Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine	Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway	0.951
ATIC	AMT	ENSP00000236959	ENSP00000273588	Bifunctional purine biosynthesis protein PURH; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family	Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine	0.962
ATIC	GART	ENSP00000236959	ENSP00000371253	Bifunctional purine biosynthesis protein PURH; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family	Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family	0.999
ATIC	MTHFD1	ENSP00000236959	ENSP00000216605	Bifunctional purine biosynthesis protein PURH; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family	C-1-tetrahydrofolate synthase, cytoplasmic; Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1; In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family	0.987
ATIC	MTHFD1L	ENSP00000236959	ENSP00000478253	Bifunctional purine biosynthesis protein PURH; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family	Monofunctional C1-tetrahydrofolate synthase, mitochondrial; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2; In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family	0.959
ATIC	MTHFD2	ENSP00000236959	ENSP00000377617	Bifunctional purine biosynthesis protein PURH; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency; Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family	0.980
ATIC	MTHFD2L	ENSP00000236959	ENSP00000379108	Bifunctional purine biosynthesis protein PURH; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family	Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2; Methylenetetrahydrofolate dehydrogenase 2 like	0.976
ATIC	MTHFR	ENSP00000236959	ENSP00000365777	Bifunctional purine biosynthesis protein PURH; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family	Methylenetetrahydrofolate reductase; Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine	0.665
ATIC	SHMT1	ENSP00000236959	ENSP00000318868	Bifunctional purine biosynthesis protein PURH; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family	Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine	0.995
ATIC	TYMS	ENSP00000236959	ENSP00000315644	Bifunctional purine biosynthesis protein PURH; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family	Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway	0.861
GART	AMT	ENSP00000371253	ENSP00000273588	Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family	Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine	0.952

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