| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AQP1 | AQP10 | ENSP00000311165 | ENSP00000318355 | Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient; Aquaporins | Aquaporin-10; Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol; Belongs to the MIP/aquaporin (TC 1.A.8) family | 0.434 |
| AQP1 | AQP11 | ENSP00000311165 | ENSP00000318770 | Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient; Aquaporins | Aquaporin-11; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes | 0.855 |
| AQP1 | AQP3 | ENSP00000311165 | ENSP00000297991 | Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient; Aquaporins | Aquaporin-3; Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an [...] | 0.442 |
| AQP1 | AQP7 | ENSP00000311165 | ENSP00000297988 | Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient; Aquaporins | Aquaporin-7; Forms a channel for water and glycerol; Aquaporins | 0.499 |
| AQP1 | AQP9 | ENSP00000311165 | ENSP00000219919 | Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient; Aquaporins | Aquaporin-9; Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol; Belongs to the MIP/aquaporin (TC 1.A.8) family | 0.436 |
| AQP10 | AQP1 | ENSP00000318355 | ENSP00000311165 | Aquaporin-10; Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol; Belongs to the MIP/aquaporin (TC 1.A.8) family | Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient; Aquaporins | 0.434 |
| AQP10 | AQP11 | ENSP00000318355 | ENSP00000318770 | Aquaporin-10; Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol; Belongs to the MIP/aquaporin (TC 1.A.8) family | Aquaporin-11; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes | 0.826 |
| AQP10 | AQP4 | ENSP00000318355 | ENSP00000372654 | Aquaporin-10; Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol; Belongs to the MIP/aquaporin (TC 1.A.8) family | Aquaporin-4; Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system; Belongs to the MIP/aquaporin (TC 1.A.8) family | 0.423 |
| AQP10 | AQP5 | ENSP00000318355 | ENSP00000293599 | Aquaporin-10; Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol; Belongs to the MIP/aquaporin (TC 1.A.8) family | Aquaporin-5; Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells; Belongs to the MIP/aquaporin (TC 1.A.8) family | 0.882 |
| AQP10 | AQP6 | ENSP00000318355 | ENSP00000477688 | Aquaporin-10; Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol; Belongs to the MIP/aquaporin (TC 1.A.8) family | Aquaporin-6; Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism; Aquaporins | 0.906 |
| AQP10 | AQP8 | ENSP00000318355 | ENSP00000219660 | Aquaporin-10; Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol; Belongs to the MIP/aquaporin (TC 1.A.8) family | Aquaporin-8; Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea; Belongs to the MIP/aquaporin (TC 1.A.8) family | 0.933 |
| AQP10 | MIP | ENSP00000318355 | ENSP00000257979 | Aquaporin-10; Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol; Belongs to the MIP/aquaporin (TC 1.A.8) family | Lens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling; Belongs to the MIP/aquaporin (TC 1.A.8) family | 0.900 |
| AQP11 | AQP1 | ENSP00000318770 | ENSP00000311165 | Aquaporin-11; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes | Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient; Aquaporins | 0.855 |
| AQP11 | AQP10 | ENSP00000318770 | ENSP00000318355 | Aquaporin-11; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes | Aquaporin-10; Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol; Belongs to the MIP/aquaporin (TC 1.A.8) family | 0.826 |
| AQP11 | AQP3 | ENSP00000318770 | ENSP00000297991 | Aquaporin-11; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes | Aquaporin-3; Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an [...] | 0.868 |
| AQP11 | AQP4 | ENSP00000318770 | ENSP00000372654 | Aquaporin-11; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes | Aquaporin-4; Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system; Belongs to the MIP/aquaporin (TC 1.A.8) family | 0.858 |
| AQP11 | AQP5 | ENSP00000318770 | ENSP00000293599 | Aquaporin-11; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes | Aquaporin-5; Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells; Belongs to the MIP/aquaporin (TC 1.A.8) family | 0.814 |
| AQP11 | AQP6 | ENSP00000318770 | ENSP00000477688 | Aquaporin-11; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes | Aquaporin-6; Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism; Aquaporins | 0.844 |
| AQP11 | AQP7 | ENSP00000318770 | ENSP00000297988 | Aquaporin-11; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes | Aquaporin-7; Forms a channel for water and glycerol; Aquaporins | 0.827 |
| AQP11 | AQP8 | ENSP00000318770 | ENSP00000219660 | Aquaporin-11; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes | Aquaporin-8; Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea; Belongs to the MIP/aquaporin (TC 1.A.8) family | 0.866 |
