| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BBOX1 | TRIM52 | ENSP00000263182 | ENSP00000483005 | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family | Tripartite motif containing 52; Ring finger proteins | 0.510 |
| BBOX1 | TRIM56 | ENSP00000263182 | ENSP00000305161 | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family | E3 ubiquitin-protein ligase TRIM56; E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity. In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets TMEM173/STING to ’Lys-63’-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXC [...] | 0.602 |
| BBOX1 | TRIM73 | ENSP00000263182 | ENSP00000318615 | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family | Tripartite motif containing 73; Belongs to the TRIM/RBCC family | 0.714 |
| BSPRY | TRIM52 | ENSP00000363298 | ENSP00000483005 | B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity | Tripartite motif containing 52; Ring finger proteins | 0.411 |
| BSPRY | TRIM73 | ENSP00000363298 | ENSP00000318615 | B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity | Tripartite motif containing 73; Belongs to the TRIM/RBCC family | 0.473 |
| C22orf39 | TRIM73 | ENSP00000382474 | ENSP00000318615 | UPF0545 protein C22orf39; Chromosome 22 open reading frame 39; Belongs to the UPF0545 family | Tripartite motif containing 73; Belongs to the TRIM/RBCC family | 0.641 |
| FAM181A | KRTAP17-1 | ENSP00000267594 | ENSP00000333993 | Protein FAM181A; Family with sequence similarity 181 member A | Keratin-associated protein 17-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins | 0.500 |
| FAM181A | RANBP3L | ENSP00000267594 | ENSP00000421853 | Protein FAM181A; Family with sequence similarity 181 member A | Ran-binding protein 3-like; Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner | 0.562 |
| FAM181A | TCEAL4 | ENSP00000267594 | ENSP00000361712 | Protein FAM181A; Family with sequence similarity 181 member A | Transcription elongation factor A protein-like 4; May be involved in transcriptional regulation; Transcription elongation factor A like family | 0.471 |
| FAM181A | TRIM73 | ENSP00000267594 | ENSP00000318615 | Protein FAM181A; Family with sequence similarity 181 member A | Tripartite motif containing 73; Belongs to the TRIM/RBCC family | 0.542 |
| KRTAP17-1 | FAM181A | ENSP00000333993 | ENSP00000267594 | Keratin-associated protein 17-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins | Protein FAM181A; Family with sequence similarity 181 member A | 0.500 |
| KRTAP17-1 | RANBP3L | ENSP00000333993 | ENSP00000421853 | Keratin-associated protein 17-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins | Ran-binding protein 3-like; Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner | 0.461 |
| KRTAP17-1 | TCEAL4 | ENSP00000333993 | ENSP00000361712 | Keratin-associated protein 17-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins | Transcription elongation factor A protein-like 4; May be involved in transcriptional regulation; Transcription elongation factor A like family | 0.420 |
| KRTAP17-1 | TRIM73 | ENSP00000333993 | ENSP00000318615 | Keratin-associated protein 17-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins | Tripartite motif containing 73; Belongs to the TRIM/RBCC family | 0.495 |
| RANBP3L | FAM181A | ENSP00000421853 | ENSP00000267594 | Ran-binding protein 3-like; Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner | Protein FAM181A; Family with sequence similarity 181 member A | 0.562 |
| RANBP3L | KRTAP17-1 | ENSP00000421853 | ENSP00000333993 | Ran-binding protein 3-like; Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner | Keratin-associated protein 17-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins | 0.461 |
| RANBP3L | TCEAL4 | ENSP00000421853 | ENSP00000361712 | Ran-binding protein 3-like; Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner | Transcription elongation factor A protein-like 4; May be involved in transcriptional regulation; Transcription elongation factor A like family | 0.443 |
| RANBP3L | TRIM73 | ENSP00000421853 | ENSP00000318615 | Ran-binding protein 3-like; Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner | Tripartite motif containing 73; Belongs to the TRIM/RBCC family | 0.530 |
| TCEAL4 | FAM181A | ENSP00000361712 | ENSP00000267594 | Transcription elongation factor A protein-like 4; May be involved in transcriptional regulation; Transcription elongation factor A like family | Protein FAM181A; Family with sequence similarity 181 member A | 0.471 |
| TCEAL4 | KRTAP17-1 | ENSP00000361712 | ENSP00000333993 | Transcription elongation factor A protein-like 4; May be involved in transcriptional regulation; Transcription elongation factor A like family | Keratin-associated protein 17-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins | 0.420 |
