| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AFF3 | KIAA0319L | ENSP00000386834 | ENSP00000318406 | AF4/FMR2 family member 3; Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double- stranded DNA; Belongs to the AF4 family | Dyslexia-associated protein KIAA0319-like protein; Possible role in axon guidance through interaction with RTN4R | 0.673 |
| AFF3 | TLK2 | ENSP00000386834 | ENSP00000316512 | AF4/FMR2 family member 3; Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double- stranded DNA; Belongs to the AF4 family | Serine/threonine-protein kinase tousled-like 2; Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy | 0.656 |
| C17orf75 | KIAA0319L | ENSP00000464275 | ENSP00000318406 | Protein Njmu-R1; May have a role in spermatogenesis | Dyslexia-associated protein KIAA0319-like protein; Possible role in axon guidance through interaction with RTN4R | 0.694 |
| CPD | KIAA0319L | ENSP00000225719 | ENSP00000318406 | M14 carboxypeptidases | Dyslexia-associated protein KIAA0319-like protein; Possible role in axon guidance through interaction with RTN4R | 0.701 |
| DCDC2 | DYX1C1 | ENSP00000367715 | ENSP00000323275 | Doublecortin domain-containing protein 2; Protein that plays a role in the inhibition of canonical Wnt signaling pathway. May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length; Deafness associated genes | Dynein assembly factor 4, axonemal; Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity | 0.909 |
| DCDC2 | KIAA0319L | ENSP00000367715 | ENSP00000318406 | Doublecortin domain-containing protein 2; Protein that plays a role in the inhibition of canonical Wnt signaling pathway. May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length; Deafness associated genes | Dyslexia-associated protein KIAA0319-like protein; Possible role in axon guidance through interaction with RTN4R | 0.683 |
| DCDC2 | TMEM138 | ENSP00000367715 | ENSP00000278826 | Doublecortin domain-containing protein 2; Protein that plays a role in the inhibition of canonical Wnt signaling pathway. May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length; Deafness associated genes | Transmembrane protein 138; Required for ciliogenesis | 0.593 |
| DYX1C1 | DCDC2 | ENSP00000323275 | ENSP00000367715 | Dynein assembly factor 4, axonemal; Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity | Doublecortin domain-containing protein 2; Protein that plays a role in the inhibition of canonical Wnt signaling pathway. May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length; Deafness associated genes | 0.909 |
| DYX1C1 | KIAA0319L | ENSP00000323275 | ENSP00000318406 | Dynein assembly factor 4, axonemal; Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity | Dyslexia-associated protein KIAA0319-like protein; Possible role in axon guidance through interaction with RTN4R | 0.677 |
| DYX1C1 | TMEM138 | ENSP00000323275 | ENSP00000278826 | Dynein assembly factor 4, axonemal; Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity | Transmembrane protein 138; Required for ciliogenesis | 0.588 |
| KIAA0319L | AFF3 | ENSP00000318406 | ENSP00000386834 | Dyslexia-associated protein KIAA0319-like protein; Possible role in axon guidance through interaction with RTN4R | AF4/FMR2 family member 3; Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double- stranded DNA; Belongs to the AF4 family | 0.673 |
| KIAA0319L | C17orf75 | ENSP00000318406 | ENSP00000464275 | Dyslexia-associated protein KIAA0319-like protein; Possible role in axon guidance through interaction with RTN4R | Protein Njmu-R1; May have a role in spermatogenesis | 0.694 |
| KIAA0319L | CPD | ENSP00000318406 | ENSP00000225719 | Dyslexia-associated protein KIAA0319-like protein; Possible role in axon guidance through interaction with RTN4R | M14 carboxypeptidases | 0.701 |
| KIAA0319L | DCDC2 | ENSP00000318406 | ENSP00000367715 | Dyslexia-associated protein KIAA0319-like protein; Possible role in axon guidance through interaction with RTN4R | Doublecortin domain-containing protein 2; Protein that plays a role in the inhibition of canonical Wnt signaling pathway. May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length; Deafness associated genes | 0.683 |
| KIAA0319L | DYX1C1 | ENSP00000318406 | ENSP00000323275 | Dyslexia-associated protein KIAA0319-like protein; Possible role in axon guidance through interaction with RTN4R | Dynein assembly factor 4, axonemal; Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity | 0.677 |
| KIAA0319L | PRKD1 | ENSP00000318406 | ENSP00000333568 | Dyslexia-associated protein KIAA0319-like protein; Possible role in axon guidance through interaction with RTN4R | Serine/threonine-protein kinase D1; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory res [...] | 0.648 |
| KIAA0319L | RTN4R | ENSP00000318406 | ENSP00000043402 | Dyslexia-associated protein KIAA0319-like protein; Possible role in axon guidance through interaction with RTN4R | Reticulon-4 receptor; Receptor for RTN4, OMG and MAG. Functions as receptor for the sialylated gangliosides GT1b and GM1. Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition. Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain develo [...] | 0.855 |
| KIAA0319L | TLK1 | ENSP00000318406 | ENSP00000411099 | Dyslexia-associated protein KIAA0319-like protein; Possible role in axon guidance through interaction with RTN4R | Serine/threonine-protein kinase tousled-like 1; Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S- phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at ’Ser-10’ | 0.683 |
| KIAA0319L | TLK2 | ENSP00000318406 | ENSP00000316512 | Dyslexia-associated protein KIAA0319-like protein; Possible role in axon guidance through interaction with RTN4R | Serine/threonine-protein kinase tousled-like 2; Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy | 0.692 |
| KIAA0319L | TMEM138 | ENSP00000318406 | ENSP00000278826 | Dyslexia-associated protein KIAA0319-like protein; Possible role in axon guidance through interaction with RTN4R | Transmembrane protein 138; Required for ciliogenesis | 0.628 |
