node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CROCC | LENG8 | ENSP00000364691 | ENSP00000318374 | Rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis. Contributes to centrosome cohesion before mitosis | Leukocyte receptor cluster member 8 | 0.660 |
CROCC | SNAPC4 | ENSP00000364691 | ENSP00000298532 | Rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis. Contributes to centrosome cohesion before mitosis | snRNA-activating protein complex subunit 4; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box; Myb/SANT domain containing | 0.840 |
CTPS2 | LENG8 | ENSP00000401264 | ENSP00000318374 | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides | Leukocyte receptor cluster member 8 | 0.693 |
CTPS2 | SAMSN1 | ENSP00000401264 | ENSP00000285670 | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides | SAM domain-containing protein SAMSN-1; Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity); SAM and SH3 domain containing | 0.526 |
CUL9 | LENG8 | ENSP00000252050 | ENSP00000318374 | Cullin-9; Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5. Cytoplasmic anchor protein in p53/TP53- associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function; Armadillo-like helical domain containing | Leukocyte receptor cluster member 8 | 0.667 |
FCAR | LENG8 | ENSP00000347714 | ENSP00000318374 | Immunoglobulin alpha Fc receptor; Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production; CD molecules | Leukocyte receptor cluster member 8 | 0.704 |
FCAR | RPS9 | ENSP00000347714 | ENSP00000302896 | Immunoglobulin alpha Fc receptor; Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production; CD molecules | Ribosomal protein S9 | 0.582 |
GIGYF1 | LENG8 | ENSP00000275732 | ENSP00000318374 | GRB10-interacting GYF protein 1; May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity); Belongs to the GIGYF family | Leukocyte receptor cluster member 8 | 0.760 |
IGSF1 | LENG8 | ENSP00000359940 | ENSP00000318374 | Immunoglobulin superfamily member 1; Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B (By similarity). Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription; Immunoglobulin like domain containing | Leukocyte receptor cluster member 8 | 0.626 |
LENG8 | CROCC | ENSP00000318374 | ENSP00000364691 | Leukocyte receptor cluster member 8 | Rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis. Contributes to centrosome cohesion before mitosis | 0.660 |
LENG8 | CTPS2 | ENSP00000318374 | ENSP00000401264 | Leukocyte receptor cluster member 8 | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides | 0.693 |
LENG8 | CUL9 | ENSP00000318374 | ENSP00000252050 | Leukocyte receptor cluster member 8 | Cullin-9; Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5. Cytoplasmic anchor protein in p53/TP53- associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function; Armadillo-like helical domain containing | 0.667 |
LENG8 | FCAR | ENSP00000318374 | ENSP00000347714 | Leukocyte receptor cluster member 8 | Immunoglobulin alpha Fc receptor; Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production; CD molecules | 0.704 |
LENG8 | GIGYF1 | ENSP00000318374 | ENSP00000275732 | Leukocyte receptor cluster member 8 | GRB10-interacting GYF protein 1; May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity); Belongs to the GIGYF family | 0.760 |
LENG8 | IGSF1 | ENSP00000318374 | ENSP00000359940 | Leukocyte receptor cluster member 8 | Immunoglobulin superfamily member 1; Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B (By similarity). Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription; Immunoglobulin like domain containing | 0.626 |
LENG8 | PCID2 | ENSP00000318374 | ENSP00000479494 | Leukocyte receptor cluster member 8 | PCI domain containing 2; Transcription and export complex 2 | 0.898 |
LENG8 | RPS9 | ENSP00000318374 | ENSP00000302896 | Leukocyte receptor cluster member 8 | Ribosomal protein S9 | 0.614 |
LENG8 | SAMSN1 | ENSP00000318374 | ENSP00000285670 | Leukocyte receptor cluster member 8 | SAM domain-containing protein SAMSN-1; Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity); SAM and SH3 domain containing | 0.651 |
LENG8 | SNAPC4 | ENSP00000318374 | ENSP00000298532 | Leukocyte receptor cluster member 8 | snRNA-activating protein complex subunit 4; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box; Myb/SANT domain containing | 0.663 |
PCID2 | LENG8 | ENSP00000479494 | ENSP00000318374 | PCI domain containing 2; Transcription and export complex 2 | Leukocyte receptor cluster member 8 | 0.898 |