AQP10 protein (human) - STRING database

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AQP10

Aquaporin-10; Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol; Belongs to the MIP/aquaporin (TC 1.A.8) family (301 aa)

Predicted Functional Partners:

AQP8

0.933

AQP6

0.906

MIP

0.900

AQP12A

0.886

AQP5

0.882

AQP11

0.826

GATA1

0.749

SLC10A4

0.515

GPR68

0.503

GK

0.502

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQP10	AQP11	ENSP00000318355	ENSP00000318770	Aquaporin-10; Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol; Belongs to the MIP/aquaporin (TC 1.A.8) family	Aquaporin-11; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes	0.826
AQP10	AQP12A	ENSP00000318355	ENSP00000405899	Aquaporin-10; Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol; Belongs to the MIP/aquaporin (TC 1.A.8) family	Aquaporin-12A; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes; Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily	0.886
AQP10	AQP5	ENSP00000318355	ENSP00000293599	Aquaporin-10; Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol; Belongs to the MIP/aquaporin (TC 1.A.8) family	Aquaporin-5; Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells; Belongs to the MIP/aquaporin (TC 1.A.8) family	0.882
AQP10	AQP6	ENSP00000318355	ENSP00000477688	Aquaporin-10; Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol; Belongs to the MIP/aquaporin (TC 1.A.8) family	Aquaporin-6; Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism; Aquaporins	0.906
AQP10	AQP8	ENSP00000318355	ENSP00000219660	Aquaporin-10; Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol; Belongs to the MIP/aquaporin (TC 1.A.8) family	Aquaporin-8; Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea; Belongs to the MIP/aquaporin (TC 1.A.8) family	0.933
AQP10	GATA1	ENSP00000318355	ENSP00000365858	Aquaporin-10; Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol; Belongs to the MIP/aquaporin (TC 1.A.8) family	Erythroid transcription factor; Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5’-[AT]GATA[AG]-3’ within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS; GATA zinc finger domain containing	0.749
AQP10	GK	ENSP00000318355	ENSP00000401720	Aquaporin-10; Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol; Belongs to the MIP/aquaporin (TC 1.A.8) family	Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism; Belongs to the FGGY kinase family	0.502
AQP10	GPR68	ENSP00000318355	ENSP00000434045	Aquaporin-10; Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol; Belongs to the MIP/aquaporin (TC 1.A.8) family	Ovarian cancer G-protein coupled receptor 1; Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer (By similarity); Belongs to the G-protein coupled receptor 1 family	0.503
AQP10	MIP	ENSP00000318355	ENSP00000257979	Aquaporin-10; Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol; Belongs to the MIP/aquaporin (TC 1.A.8) family	Lens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling; Belongs to the MIP/aquaporin (TC 1.A.8) family	0.900
AQP10	SLC10A4	ENSP00000318355	ENSP00000273861	Aquaporin-10; Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol; Belongs to the MIP/aquaporin (TC 1.A.8) family	Sodium/bile acid cotransporter 4; Transporter for bile acids; Belongs to the bile acid-sodium symporter (BASS) (TC 2.A.28) family	0.515
AQP11	AQP10	ENSP00000318770	ENSP00000318355	Aquaporin-11; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes	Aquaporin-10; Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol; Belongs to the MIP/aquaporin (TC 1.A.8) family	0.826
AQP11	AQP5	ENSP00000318770	ENSP00000293599	Aquaporin-11; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes	Aquaporin-5; Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells; Belongs to the MIP/aquaporin (TC 1.A.8) family	0.814
AQP11	AQP6	ENSP00000318770	ENSP00000477688	Aquaporin-11; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes	Aquaporin-6; Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism; Aquaporins	0.844
AQP11	AQP8	ENSP00000318770	ENSP00000219660	Aquaporin-11; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes	Aquaporin-8; Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea; Belongs to the MIP/aquaporin (TC 1.A.8) family	0.866
AQP11	MIP	ENSP00000318770	ENSP00000257979	Aquaporin-11; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes	Lens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling; Belongs to the MIP/aquaporin (TC 1.A.8) family	0.877
AQP12A	AQP10	ENSP00000405899	ENSP00000318355	Aquaporin-12A; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes; Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily	Aquaporin-10; Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol; Belongs to the MIP/aquaporin (TC 1.A.8) family	0.886
AQP12A	AQP5	ENSP00000405899	ENSP00000293599	Aquaporin-12A; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes; Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily	Aquaporin-5; Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells; Belongs to the MIP/aquaporin (TC 1.A.8) family	0.846
AQP12A	AQP6	ENSP00000405899	ENSP00000477688	Aquaporin-12A; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes; Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily	Aquaporin-6; Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism; Aquaporins	0.867
AQP12A	AQP8	ENSP00000405899	ENSP00000219660	Aquaporin-12A; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes; Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily	Aquaporin-8; Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea; Belongs to the MIP/aquaporin (TC 1.A.8) family	0.903
AQP12A	MIP	ENSP00000405899	ENSP00000257979	Aquaporin-12A; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes; Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily	Lens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling; Belongs to the MIP/aquaporin (TC 1.A.8) family	0.916

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