• Version:
  • 11.0 [archived version]
STRINGSTRING
CDHR1 CDHR1 KCNIP3 KCNIP3 AJAP1 AJAP1 LETM2 LETM2 SPRN SPRN PDZD2 PDZD2 PROM2 PROM2 PRND PRND FAM184A FAM184A ZNF514 ZNF514 NIPAL2 NIPAL2
"PROM2" - Prominin-2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PROM2Prominin-2; Prominin 2 (834 aa)    
Predicted Functional Partners:
LETM2
LETM1 domain-containing protein LETM2, mitochondrial; Leucine zipper and EF-hand containing transmembrane protein 2 (491 aa)
           
  0.705
PRND
Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+); Belongs to the prion family (176 aa)
           
  0.658
FAM184A
Protein FAM184A; Family with sequence similarity 184 member A (1140 aa)
           
  0.620
CDHR1
Cadherin-related family member 1; Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity); Cadherin related (859 aa)
           
  0.591
PDZD2
PDZ domain containing 2 (2839 aa)
           
  0.576
KCNIP3
Calsenilin; Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity); EF-hand domain containing (256 aa)
           
  0.552
SPRN
Shadow of prion protein; Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity) (151 aa)
           
  0.534
NIPAL2
NIPA-like protein 2; NIPA like domain containing 2; Belongs to the NIPA family (368 aa)
           
  0.512
ZNF514
Zinc finger protein 514; May be involved in transcriptional regulation; Zinc fingers C2H2-type (400 aa)
           
  0.503
AJAP1
Adherens junction-associated protein 1; Plays a role in cell adhesion and cell migration (411 aa)
           
  0.501
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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